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Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ATP-bound Mpa ATPase

Source organism: Mycobacterium tuberculosis
Biochemical function: protein binding
Biological process: symbiont-mediated perturbation of host defenses
Cellular component: plasma membrane

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EC 3.4.25.1: Proteasome endopeptidase complex

Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Alternative Name(s):
  • 26S protease
  • Alkaline protease
  • Ingensin
  • Large multicatalytic protease
  • Lens neutral proteinase
  • MCP
  • Macropain
  • Multicatalytic endopeptidase complex
  • Multicatalytic proteinase
  • Multicatalytic proteinase (complex)
  • Prosome
  • Proteasome
  • Proteasome organelle
  • Tricorn protease
  • Tricorn proteinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00227
Domain description: Proteasome subunit
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. Proteasome-associated ATPase

PF16450
Domain description: Proteasomal ATPase OB C-terminal domain
Occurring in:
  1. Proteasome-associated ATPase

PF17758
Domain description: Proteasomal ATPase OB N-terminal domain
Occurring in:
  1. Proteasome-associated ATPase

InterPro InterPro annotations
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta
IPR023333
Domain description: Proteasome B-type subunit
Occurring in:
  1. Proteasome subunit beta
IPR022483
Domain description: Proteasome subunit beta, actinobacteria
Occurring in:
  1. Proteasome subunit beta
IPR001353
Domain description: Proteasome, subunit alpha/beta
Occurring in:
  1. Proteasome subunit alpha
  2. Proteasome subunit beta
IPR022296
Domain description: Proteasome, alpha subunit, bacterial
Occurring in:
  1. Proteasome subunit alpha
IPR023332
Domain description: Proteasome alpha-type subunit
Occurring in:
  1. Proteasome subunit alpha
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Proteasome-associated ATPase
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. Proteasome-associated ATPase
IPR022482
Domain description: Proteasome ATPase
Occurring in:
  1. Proteasome-associated ATPase
IPR003960
Domain description: ATPase, AAA-type, conserved site
Occurring in:
  1. Proteasome-associated ATPase
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. Proteasome-associated ATPase
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Proteasome-associated ATPase
IPR032501
Domain description: Proteasomal ATPase, second OB domain
Occurring in:
  1. Proteasome-associated ATPase
IPR041626
Domain description: Proteasomal ATPase, N-terminal OB domain
Occurring in:
  1. Proteasome-associated ATPase

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