8deq

Electron Microscopy
6Å resolution

Cryo-EM local refinement of antibody SKV09 in complex with VEEV alphavirus spike glycoprotein

Released:

Function and Biology Details

Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-529343 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein E1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 402 amino acids
Theoretical weight: 43.67 KDa
Source organism: Venezuelan equine encephalitis virus
Expression system: Homo sapiens
SKV09 Fab Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 120 amino acids
Theoretical weight: 13.1 KDa
Source organism: Macaca
Expression system: Homo sapiens
SKV09 Fab Light Chain Chain: L
Molecule details ›
Chain: L
Length: 107 amino acids
Theoretical weight: 11.76 KDa
Source organism: Macaca
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-27395
Expression system: Homo sapiens