Structure analysis

Cryo-EM local refinement of antibody SKV09 in complex with VEEV alphavirus spike glycoprotein

Electron Microscopy
6Å resolution
Assembly composition:
hetero octamer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero octamer
Accessible surface area: 122005.72 Å2
Buried surface area: 4540.16 Å2
Dissociation area: 1,617.63 Å2
Dissociation energy (ΔGdiss): -64.62 kcal/mol
Dissociation entropy (TΔSdiss): 74.56 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-272344

Macromolecules

Chains: A, B, C, D, E, F
Length: 402 amino acids
Theoretical weight: 43.67 KDa
Source organism: Venezuelan equine encephalitis virus
Expression system: Homo sapiens
140250100150200250300350400
 
100200300400YEHATTMPSQAGISYNTIVNRAGYAPLPISITPTKIKLIPTVNLEYVTCHYKTGMDSPAIKCCGSQECTPTYRPDEQCKVFTGVYPFMWGGAYCFCDTENTQVSKAYVMKSDDCLADHAEAYKAHTASVQAFLNITVGEHSIVTTVYVNGETPVNFNGVKITAGPLSTAWTPFDRKIVQYAGEIYNYDFPEYGAGQPGAFGDIQSRTVSSSDLYANTNLVLQRPKAGAIHVPYTQAPSGFEQWKKDKAPSLKFTAPFGCEIYTNPIRAENCAVGSIPLAFDIPDALFTRVSETPTLSAAECTLNECVYSSDFGGIATVKYSASKSGKCAVHVPSGTATLKEAAVELTEQGSATIHFSTANIHPEFRLQICTSYVTCKGDCHPPKDHIVTHPQYHAQTFTAAV
UniProt
P05674
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation

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Chain: H
Length: 120 amino acids
Theoretical weight: 13.1 KDa
Source organism: Macaca
Expression system: Homo sapiens
1120102030405060708090100110120
 
50100QVQLQESGPGLVKPSETLSLTCTVSGGSISGYYWNWIRQSPGKGLEWIGNMYDSTGDTNYNPSLKSRVTLSIDTSKNQFSMKLNSVTAADTAVYFCASGSGDWFGYFYRWGQGVLVTVSS
Chains
Chain G (auth H)
Secondary structure
Sequence conservation

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Chain: L
Length: 107 amino acids
Theoretical weight: 11.76 KDa
Source organism: Macaca
Expression system: Homo sapiens
1107102030405060708090100
 
50100DIQMTQSPSSLSASVGDTVTITCRASQSISSWLAWYQQKPGKAPNLLIYKASSLQTGVPSRFSGSGSETHFTLTISSLQSEDFATYYCQQYISRPWTFGQGTKVEIK
Chains
Chain H (auth L)
Secondary structure
Sequence conservation

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