Function and Biology

Cryo-EM local refinement of antibody SKV16 in complex with VEEV alphavirus spike glycoprotein

Source organisms:
Biochemical function: serine-type endopeptidase activity
Biological process: not assigned
Cellular component: viral capsid

EC 3.4.21.90: Togavirin

Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Alternative Name(s):
  • NsP2 proteinase
  • Sindbis virus core protein
  • Sindbis virus protease

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01589
Domain description: Alphavirus E1 glycoprotein
Occurring in:
  1. Spike glycoprotein E1
The deposited structure of PDB entry 8der contains 3 copies of Pfam domain PF01589 (Alphavirus E1 glycoprotein) in Spike glycoprotein E1. Showing 1 copy in chain D [auth E].

PF00943
Domain description: Alphavirus E2 glycoprotein
Occurring in:
  1. Spike glycoprotein E2
The deposited structure of PDB entry 8der contains 3 copies of Pfam domain PF00943 (Alphavirus E2 glycoprotein) in Spike glycoprotein E2. Showing 1 copy in chain G [auth B].