› › Structure analysis

S. CEREVISIAE CYP51 COMPLEXED WITH Courmarin-containing INHIBITOR

X-ray diffraction
1.91Å resolution
PDB entry 8dl4 coloured by chain, front view.
PDB entry 8dl4 coloured by chain, side view.
PDB entry 8dl4 coloured by chain, top view.
Source organism: Saccharomyces cerevisiae YJM789
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lanosterol 14-alpha demethylase CYP51
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Multimeric state: monomeric
Accessible surface area: 23521.53 Å2
Buried surface area: 2101.57 Å2
Dissociation area: 189.13 Å2
Dissociation energy (ΔGdiss): -1.88 kcal/mol
Dissociation entropy (TΔSdiss): 2.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145359

Macromolecules

Lanosterol 14-alpha demethylase CYP51
Chain: A
Length: 539 amino acids
Theoretical weight: 61.89 KDa
Source organism: Saccharomyces cerevisiae YJM789
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P10614 (Residues: 1-530; Coverage: 100%)
Gene names: CYP51, ERG11, YHR007C
Pfam: Cytochrome P450
InterPro:
Lanosterol 14-alpha demethylase CYP51 in PDB entry 8dl4, assembly 1, front view.
Lanosterol 14-alpha demethylase CYP51 in PDB entry 8dl4, assembly 1, side view.
Lanosterol 14-alpha demethylase CYP51 in PDB entry 8dl4, assembly 1, top view.
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