Structure analysis

Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)

Electron Microscopy
2.77Å resolution
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 35456.01 Å2
Buried surface area: 3499.51 Å2
Dissociation area: 867.35 Å2
Dissociation energy (ΔGdiss): -1.78 kcal/mol
Dissociation entropy (TΔSdiss): 13.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-144194

Macromolecules

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Chain: D
Length: 606 amino acids
Theoretical weight: 70.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 18-615; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Pfam: Angiotensin-converting enzyme
InterPro: Peptidase M2, peptidyl-dipeptidase A

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