› 8dn4

Electron Microscopy
4.1Å resolution

Cryo-EM structure of human Glycine Receptor alpha-1 beta heteromer, glycine-bound state3(desensitized state)

Released:
DOI: 10.2210/pdb8dn4/pdb
PDB entry 8dn4 coloured by chain, front view.
PDB entry 8dn4 coloured by chain, side view.
PDB entry 8dn4 coloured by chain, top view.
Source organisms:
Primary publication:
Asymmetric gating of a human hetero-pentameric glycine receptor.
Liu X, Wang W
OpenAccess logo Nat Commun 14 6377 (2023)
PMID: 37821459
Related structures: EMD-27554

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-237589 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glycine receptor subunit alpha-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 367 amino acids
Theoretical weight: 42.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23415 (Residues: 29-457; Coverage: 86%)
  • Best match: P23415-2 (Residues: 29-449)
Gene name: GLRA1
Sequence domains:
Glycine receptor subunit beta; Green fluorescent protein Chain: E
Molecule details ›
Chain: E
Length: 681 amino acids
Theoretical weight: 76.7 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P48167 (Residues: 25-356, 396-497; Coverage: 91%)
  • Canonical: P42212 (Residues: 1-238; Coverage: 100%)
Gene names: GFP, GLRB
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand NAG 5 x NAG
Ligand LNK 1 x LNK
Ligand HEX 9 x HEX
Ligand NBU 3 x NBU
Ligand OCT 1 x OCT
Ligand DD9 1 x DD9
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-27554
Expression system: Homo sapiens

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