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Cryo-EM structure of human Glycine Receptor alpha-1 beta heteromer, glycine-bound state3(desensitized state)

Electron Microscopy
4.1Å resolution
PDB entry 8dn4 coloured by chain, front view.
PDB entry 8dn4 coloured by chain, side view.
PDB entry 8dn4 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycine receptor
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Multimeric state: hetero pentamer
Accessible surface area: 73810.72 Å2
Buried surface area: 27349.74 Å2
Dissociation area: 4,737.46 Å2
Dissociation energy (ΔGdiss): 54.09 kcal/mol
Dissociation entropy (TΔSdiss): 15.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-237589

Macromolecules

Glycine receptor subunit alpha-1
Chains: A, B, C, D
Length: 367 amino acids
Theoretical weight: 42.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23415 (Residues: 29-457; Coverage: 86%)
  • Best match: P23415-2 (Residues: 29-449)
Gene name: GLRA1
Pfam:
Glycine receptor subunit alpha-1 in PDB entry 8dn4, assembly 1, front view.
Glycine receptor subunit alpha-1 in PDB entry 8dn4, assembly 1, side view.
Glycine receptor subunit alpha-1 in PDB entry 8dn4, assembly 1, top view.
Molecule details ›

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Glycine receptor subunit beta; Green fluorescent protein
Chain: E
Length: 681 amino acids
Theoretical weight: 76.7 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P48167 (Residues: 25-356, 396-497; Coverage: 91%)
  • Canonical: P42212 (Residues: 1-238; Coverage: 100%)
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Gene names: GFP, GLRB
Pfam:
Glycine receptor beta in PDB entry 8dn4, assembly 1, front view.
Glycine receptor beta in PDB entry 8dn4, assembly 1, side view.
Glycine receptor beta in PDB entry 8dn4, assembly 1, top view.
Molecule details ›

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