8dnx

Electron Microscopy
2.98Å resolution

Cryo-EM structure of the human Sec61 complex inhibited by cotransin

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-216344 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Protein transport protein Sec61 subunit gamma Chain: B
Molecule details ›
Chain: B
Length: 68 amino acids
Theoretical weight: 7.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P60059 (Residues: 1-68; Coverage: 100%)
Gene name: SEC61G
Sequence domains: SecE/Sec61-gamma subunits of protein translocation complex
Protein transport protein Sec61 subunit beta Chain: C
Molecule details ›
Chain: C
Length: 96 amino acids
Theoretical weight: 9.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P60468 (Residues: 1-96; Coverage: 100%)
Gene name: SEC61B
Sequence domains: Sec61beta family
Protein transport protein Sec61 subunit alpha isoform 1 Chain: A
Molecule details ›
Chain: A
Length: 476 amino acids
Theoretical weight: 52.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P61619 (Residues: 1-476; Coverage: 100%)
Gene names: SEC61A, SEC61A1
Sequence domains:
Cotransin analogue peptide inhibitor Chain: D
Molecule details ›
Chain: D
Length: 7 amino acids
Theoretical weight: 953 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
2 modified residues:

Experiments and Validation Details

Entry percentile scores
Resolution: 2.98Å
Relevant EMDB volumes: EMD-27583
Expression systems:
  • Spodoptera frugiperda
  • Not provided