› 8dnx

Electron Microscopy
2.98Å resolution

Cryo-EM structure of the human Sec61 complex inhibited by cotransin

Released:
DOI: 10.2210/pdb8dnx/pdb
PDB entry 8dnx coloured by chain, front view.
PDB entry 8dnx coloured by chain, side view.
PDB entry 8dnx coloured by chain, top view.
Source organisms:
Primary publication:
A common mechanism of Sec61 translocon inhibition by small molecules.
Itskanov S, Wang L, Junne T, Sherriff R, Xiao L, Blanchard N, Shi WQ, Forsyth C, Hoepfner D, Spiess M, Park E
Nat Chem Biol (2023)
PMID: 37169959
Related structures: EMD-27583

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-274019 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Protein transport protein Sec61 subunit gamma Chain: B
Molecule details ›
Chain: B
Length: 68 amino acids
Theoretical weight: 7.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Protein transport protein Sec61 subunit beta Chain: C
Molecule details ›
Chain: C
Length: 96 amino acids
Theoretical weight: 9.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Protein transport protein Sec61 subunit alpha isoform 1 Chain: A
Cotransin analogue peptide inhibitor Chain: D

Ligands and Environments

No bound ligands
2 modified residues:
Ligand MLE 1 x MLE
Ligand MAA 1 x MAA

Experiments and Validation Details

Entry percentile scores
Resolution: 2.98Å
Relevant EMDB volumes: EMD-27583
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

1 review citation

From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone.
Ricci et al. (2023)
5 other articles