Structure analysis

Cryo-EM structure of the human Sec61 complex inhibited by cotransin

Electron Microscopy
2.98Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 26765.08 Å2
Buried surface area: 7117.48 Å2
Dissociation area: 566.47 Å2
Dissociation energy (ΔGdiss): 3.9 kcal/mol
Dissociation entropy (TΔSdiss): 6.71 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-274019

Macromolecules

Chain: B
Length: 68 amino acids
Theoretical weight: 7.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
1685101520253035404550556065
 
204060MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG
UniProt
P60059
Chains
Secondary structure
Interaction interfaces

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Chain: C
Length: 96 amino acids
Theoretical weight: 9.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
196102030405060708090
 
50MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
UniProt
P60468
Chains
Secondary structure
Flexibility predictions
Interaction interfaces

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Chain: A
Length: 476 amino acids
Theoretical weight: 52.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
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Chain: D
Length: 7 amino acids
Theoretical weight: 953 Da
Source organism: synthetic construct
Expression system: Not provided
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