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Cryo-EM structure of the human Sec61 complex inhibited by cotransin

Electron Microscopy
2.98Å resolution
PDB entry 8dnx coloured by chain, front view.
PDB entry 8dnx coloured by chain, side view.
PDB entry 8dnx coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 26765.08 Å2
Buried surface area: 7117.48 Å2
Dissociation area: 566.47 Å2
Dissociation energy (ΔGdiss): 3.9 kcal/mol
Dissociation entropy (TΔSdiss): 6.71 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-274019

Macromolecules

Protein transport protein Sec61 subunit gamma
Chain: B
Length: 68 amino acids
Theoretical weight: 7.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P60059 (Residues: 1-68; Coverage: 100%)
Gene name: SEC61G
Pfam: SecE/Sec61-gamma subunits of protein translocation complex
Protein transport protein Sec61 subunit gamma in PDB entry 8dnx, assembly 1, front view.
Protein transport protein Sec61 subunit gamma in PDB entry 8dnx, assembly 1, side view.
Protein transport protein Sec61 subunit gamma in PDB entry 8dnx, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P60059  
1685101520253035404550556065
 
204060MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG
UniProt
P60059
Chains
Secondary structure
Interaction interfaces
Sequence conservation
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Protein transport protein Sec61 subunit beta
Chain: C
Length: 96 amino acids
Theoretical weight: 9.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P60468 (Residues: 1-96; Coverage: 100%)
Gene name: SEC61B
Pfam: Sec61beta family
Protein transport protein Sec61 subunit beta in PDB entry 8dnx, assembly 1, front view.
Protein transport protein Sec61 subunit beta in PDB entry 8dnx, assembly 1, side view.
Protein transport protein Sec61 subunit beta in PDB entry 8dnx, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P60468  
196102030405060708090
 
50MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
UniProt
P60468
Chains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
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Protein transport protein Sec61 subunit alpha isoform 1
Chain: A
Length: 476 amino acids
Theoretical weight: 52.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P61619 (Residues: 1-476; Coverage: 100%)
Gene names: SEC61A, SEC61A1
Pfam:
Protein transport protein Sec61 subunit alpha isoform 1 in PDB entry 8dnx, assembly 1, front view.
Protein transport protein Sec61 subunit alpha isoform 1 in PDB entry 8dnx, assembly 1, side view.
Protein transport protein Sec61 subunit alpha isoform 1 in PDB entry 8dnx, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P61619  
147650100150200250300350400450
 
200400MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRYELPIRSTKVRGQIGIYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSPRDIAKQFKDQGMVINGKRETSIYRELKKIIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
UniProt
P61619
Chains
Secondary structure
Interaction interfaces
Sequence conservation
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Cotransin analogue peptide inhibitor
Chain: D
Length: 7 amino acids
Theoretical weight: 953 Da
Source organism: synthetic construct
Expression system: Not provided
Cotransin analogue peptide inhibitor in PDB entry 8dnx, assembly 1, front view.
Cotransin analogue peptide inhibitor in PDB entry 8dnx, assembly 1, side view.
Cotransin analogue peptide inhibitor in PDB entry 8dnx, assembly 1, top view.
171.01.52.02.53.03.54.04.55.05.56.06.57.0
 
2468**L*L**
Chains
Chain D (auth D)
Interaction interfaces
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