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Estrogen Receptor Alpha Ligand Binding Domain in Complex with (6'-hydroxy-1'-(4-(2-(1-propylpyrrolidin-3-yl)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone

X-ray diffraction
1.81Å resolution
PDB entry 8dud coloured by chain, front view.
PDB entry 8dud coloured by chain, side view.
PDB entry 8dud coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Estrogen receptor
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Multimeric state: homo dimer
Accessible surface area: 19860.02 Å2
Buried surface area: 2730.59 Å2
Dissociation area: 1,365.3 Å2
Dissociation energy (ΔGdiss): 2.87 kcal/mol
Dissociation entropy (TΔSdiss): 13.15 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136919

Macromolecules

Estrogen receptor
Chain: A
Length: 255 amino acids
Theoretical weight: 29.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 301-554; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
Estrogen receptor in PDB entry 8dud, assembly 1, front view.
Estrogen receptor in PDB entry 8dud, assembly 1, side view.
Estrogen receptor in PDB entry 8dud, assembly 1, top view.
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