Function and Biology

Cryo-EM structure of SARS-CoV-2 RBD in complex with anti-SARS-CoV-2 DARPin,SR16m, and two antibody Fabs, S309 and CR3022

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF09408
Domain description: Betacoronavirus spike glycoprotein S1, receptor binding
Occurring in:
  1. Spike protein S1
The deposited structure of PDB entry 8dw3 contains 1 copy of Pfam domain PF09408 (Betacoronavirus spike glycoprotein S1, receptor binding) in Spike protein S1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002110
Domain description: Ankyrin repeat
Occurring in:
  1. Anti-SARS-CoV-2 DARPin SR16m
IPR003597
IPR013106
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Antibody S309 light chain
  2. antibody S309 heavy chain
  3. antibody CR3022 heavy chain
  4. antibody CR3022 light chain
IPR013783
IPR007110
IPR003599
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Antibody S309 light chain
  2. antibody S309 heavy chain
  3. antibody CR3022 heavy chain
  4. antibody CR3022 light chain
IPR036770
Domain description: Ankyrin repeat-containing domain superfamily
Occurring in:
  1. Anti-SARS-CoV-2 DARPin SR16m
IPR018548
Domain description: Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
Occurring in:
  1. Spike protein S1
IPR036326
Domain description: Spike S1 subunit, receptor binding domain superfamily, betacoronavirus
Occurring in:
  1. Spike protein S1