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Cryo-EM structure of Importin-4 bound to RanGTP

Electron Microscopy
7.1Å resolution
PDB entry 8dyo coloured by chain, front view.
PDB entry 8dyo coloured by chain, side view.
PDB entry 8dyo coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GTP-binding nuclear protein GSP1/CNR1 and Importin-4
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Multimeric state: hetero dimer
Accessible surface area: 64568.75 Å2
Buried surface area: 3317.17 Å2
Dissociation area: 1,221.82 Å2
Dissociation energy (ΔGdiss): -5.48 kcal/mol
Dissociation entropy (TΔSdiss): 13.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152468

Macromolecules

Importin-4
Chain: A
Length: 1081 amino acids
Theoretical weight: 118.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TEX9 (Residues: 1-1081; Coverage: 100%)
  • Best match: Q8TEX9-2 (Residues: 1-1083)
Gene names: IMP4B, IPO4, RANBP4
Pfam:
InterPro:
Importin-4 in PDB entry 8dyo, assembly 1, front view.
Importin-4 in PDB entry 8dyo, assembly 1, side view.
Importin-4 in PDB entry 8dyo, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q8TEX9  
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Molecule details ›

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GTP-binding nuclear protein GSP1/CNR1
Chain: B
Length: 219 amino acids
Theoretical weight: 24.83 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P32835 (Residues: 1-219; Coverage: 100%)
Gene names: CNR1, CST17, GSP1, L8003.19, YLR293C
Pfam: Ras family
InterPro:
GTP-binding nuclear protein GSP1/CNR1 in PDB entry 8dyo, assembly 1, front view.
GTP-binding nuclear protein GSP1/CNR1 in PDB entry 8dyo, assembly 1, side view.
GTP-binding nuclear protein GSP1/CNR1 in PDB entry 8dyo, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P32835  
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Molecule details ›

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