8e5a

Electron Microscopy
3.3Å resolution

Human L-type voltage-gated calcium channel Cav1.3 treated with 1.4 mM Sofosbuvir at 3.3 Angstrom resolution

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-156982 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Voltage-dependent L-type calcium channel subunit alpha-1D Chain: A
Molecule details ›
Chain: A
Length: 2161 amino acids
Theoretical weight: 245.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q01668 (Residues: 1-2161; Coverage: 100%)
Gene names: CACH3, CACN4, CACNA1D, CACNL1A2, CCHL1A2
Sequence domains:
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: D
Molecule details ›
Chain: D
Length: 1103 amino acids
Theoretical weight: 124.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54289 (Residues: 1-1103; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A, MHS3
Sequence domains:
Voltage-dependent L-type calcium channel subunit beta-3 Chain: C
Molecule details ›
Chain: C
Length: 484 amino acids
Theoretical weight: 54.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54284 (Residues: 1-484; Coverage: 100%)
Gene names: CACNB3, CACNLB3
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-27908
Expression system: Homo sapiens