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Human L-type voltage-gated calcium channel Cav1.3 treated with 1.4 mM Sofosbuvir at 3.3 Angstrom resolution

Electron Microscopy
3.3Å resolution
PDB entry 8e5a coloured by chain, front view.
PDB entry 8e5a coloured by chain, side view.
PDB entry 8e5a coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Voltage-dependent calcium channel
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Multimeric state: hetero trimer
Accessible surface area: 123702.74 Å2
Buried surface area: 8450.47 Å2
Dissociation area: 963.28 Å2
Dissociation energy (ΔGdiss): 3.82 kcal/mol
Dissociation entropy (TΔSdiss): 14.85 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156982

Macromolecules

Voltage-dependent L-type calcium channel subunit alpha-1D
Chain: A
Length: 2161 amino acids
Theoretical weight: 245.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q01668 (Residues: 1-2161; Coverage: 100%)
Gene names: CACH3, CACN4, CACNA1D, CACNL1A2, CCHL1A2
Pfam:
InterPro:
Voltage-dependent L-type calcium channel subunit alpha-1D in PDB entry 8e5a, assembly 1, front view.
Voltage-dependent L-type calcium channel subunit alpha-1D in PDB entry 8e5a, assembly 1, side view.
Voltage-dependent L-type calcium channel subunit alpha-1D in PDB entry 8e5a, assembly 1, top view.
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Voltage-dependent calcium channel subunit alpha-2/delta-1
Chain: D
Length: 1103 amino acids
Theoretical weight: 124.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54289 (Residues: 1-1103; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A, MHS3
Pfam:
InterPro:
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8e5a, assembly 1, front view.
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8e5a, assembly 1, side view.
Voltage-dependent calcium channel subunit alpha-2/delta-1 in PDB entry 8e5a, assembly 1, top view.
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Voltage-dependent L-type calcium channel subunit beta-3
Chain: C
Length: 484 amino acids
Theoretical weight: 54.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54284 (Residues: 1-484; Coverage: 100%)
Gene names: CACNB3, CACNLB3
Pfam:
InterPro:
Voltage-dependent L-type calcium channel subunit beta-3 in PDB entry 8e5a, assembly 1, front view.
Voltage-dependent L-type calcium channel subunit beta-3 in PDB entry 8e5a, assembly 1, side view.
Voltage-dependent L-type calcium channel subunit beta-3 in PDB entry 8e5a, assembly 1, top view.
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