› 8e5a

Electron Microscopy
3.3Å resolution

Human L-type voltage-gated calcium channel Cav1.3 treated with 1.4 mM Sofosbuvir at 3.3 Angstrom resolution

Released:
DOI: 10.2210/pdb8e5a/pdb
PDB entry 8e5a coloured by chain, front view.
PDB entry 8e5a coloured by chain, side view.
PDB entry 8e5a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels.
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022)
PMID: 36417914
Related structures: EMD-27908

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156982 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Voltage-dependent L-type calcium channel subunit alpha-1D Chain: A
Molecule details ›
Chain: A
Length: 2161 amino acids
Theoretical weight: 245.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q01668 (Residues: 1-2161; Coverage: 100%)
Gene names: CACH3, CACN4, CACNA1D, CACNL1A2, CCHL1A2
Sequence domains:
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: D
Molecule details ›
Chain: D
Length: 1103 amino acids
Theoretical weight: 124.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54289 (Residues: 1-1103; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A, MHS3
Sequence domains:
Voltage-dependent L-type calcium channel subunit beta-3 Chain: C
Molecule details ›
Chain: C
Length: 484 amino acids
Theoretical weight: 54.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54284 (Residues: 1-484; Coverage: 100%)
Gene names: CACNB3, CACNLB3
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand CA 2 x CA
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-27908
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Structural biology and molecular pharmacology of voltage-gated ion channels.
Huang et al. (2024)
4 other articles

2 mentions without citation

Structural biology of voltage-gated calcium channels.
Yao et al. (2024)
1 more