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Structure of a human EMC:human Cav1.2 channel complex in GDN detergent

Source organisms:
Biochemical function: membrane insertase activity
Biological process: tail-anchored membrane protein insertion into ER membrane
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00520
Domain description: Ion transport protein
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
The deposited structure of PDB entry 8eoi contains 6 copies of Pfam domain PF00520 (Ion transport protein) in Voltage-dependent L-type calcium channel subunit alpha-1C. Showing 6 copies in chain I [auth K] (some of the copies are out of the observed residue ranges!).

PF08763
Domain description: Voltage gated calcium channel IQ domain
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF08763 (Voltage gated calcium channel IQ domain) in Voltage-dependent L-type calcium channel subunit alpha-1C. Showing 1 copy in chain I [auth K].

PF16905
Domain description: Voltage-dependent L-type calcium channel, IQ-associated
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF16905 (Voltage-dependent L-type calcium channel, IQ-associated) in Voltage-dependent L-type calcium channel subunit alpha-1C. Showing 1 copy in chain I [auth K].

PF08016
Domain description: Polycystin cation channel
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit alpha-1C

PF00625
Domain description: Guanylate kinase
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF00625 (Guanylate kinase) in Voltage-dependent L-type calcium channel subunit beta-3. Showing 1 copy in chain J.

PF12052
Domain description: Voltage gated calcium channel subunit beta domain 4Aa N terminal
Occurring in:
  1. Voltage-dependent L-type calcium channel subunit beta-3
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF12052 (Voltage gated calcium channel subunit beta domain 4Aa N terminal) in Voltage-dependent L-type calcium channel subunit beta-3. Showing 1 copy in chain J.

PF21203
Domain description: ER membrane protein complex subunit 10
Occurring in:
  1. ER membrane protein complex subunit 10

PF03665
Domain description: Uncharacterised protein family (UPF0172)
Occurring in:
  1. ER membrane protein complex subunit 8
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF03665 (Uncharacterised protein family (UPF0172)) in ER membrane protein complex subunit 8. Showing 1 copy in chain G [auth H].

PF09430
Domain description: ER membrane protein complex subunit 7, beta-sandwich domain
Occurring in:
  1. Endoplasmic reticulum membrane protein complex subunit 7
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF09430 (ER membrane protein complex subunit 7, beta-sandwich domain) in ER membrane protein complex subunit 7. Showing 1 copy in chain F [auth G].

PF07019
Domain description: EMC6
Occurring in:
  1. ER membrane protein complex subunit 6
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF07019 (EMC6) in ER membrane protein complex subunit 6. Showing 1 copy in chain E [auth F].

PF10270
Domain description: Membrane magnesium transporter
Occurring in:
  1. ER membrane protein complex subunit 5
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF10270 (Membrane magnesium transporter) in ER membrane protein complex subunit 5. Showing 1 copy in chain D [auth E].

PF06417
Domain description: Protein of unknown function (DUF1077)
Occurring in:
  1. ER membrane protein complex subunit 4
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF06417 (Protein of unknown function (DUF1077)) in ER membrane protein complex subunit 4. Showing 1 copy in chain K [auth D].

PF01956
Domain description: Integral membrane protein EMC3/TMCO1-like
Occurring in:
  1. ER membrane protein complex subunit 3
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF01956 (Integral membrane protein EMC3/TMCO1-like) in ER membrane protein complex subunit 3. Showing 1 copy in chain C.

PF22890
Domain description: EMC2 TPR-like repeat domain
Occurring in:
  1. ER membrane protein complex subunit 2

PF07774
Domain description: ER membrane protein complex subunit 1, C-terminal
Occurring in:
  1. ER membrane protein complex subunit 1
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF07774 (ER membrane protein complex subunit 1, C-terminal) in ER membrane protein complex subunit 1. Showing 1 copy in chain A.

PF13360
Domain description: PQQ-like domain
Occurring in:
  1. ER membrane protein complex subunit 1
The deposited structure of PDB entry 8eoi contains 1 copy of Pfam domain PF13360 (PQQ-like domain) in ER membrane protein complex subunit 1. Showing 1 copy in chain A.

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