› 8esd

X-ray diffraction
3.33Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-216428 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
COMM domain-containing protein 10 Chain: T
Molecule details ›
Chain: T
Length: 191 amino acids
Theoretical weight: 21.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6G5 (Residues: 12-202; Coverage: 95%)
Gene names: COMMD10, HSPC305, PTD002
Sequence domains:
COMM domain-containing protein 9 Chain: N
Molecule details ›
Chain: N
Length: 194 amino acids
Theoretical weight: 21.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P000 (Residues: 5-198; Coverage: 98%)
Gene names: COMMD9, HSPC166
Sequence domains:
COMM domain-containing protein 5 Chain: F
Molecule details ›
Chain: F
Length: 75 amino acids
Theoretical weight: 8.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZQ3 (Residues: 149-222; Coverage: 33%)
Gene names: COMMD5, HT002
Sequence domains: COMM domain
COMM domain-containing protein 7 Chain: S
Molecule details ›
Chain: S
Length: 70 amino acids
Theoretical weight: 8.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86VX2 (Residues: 131-200; Coverage: 35%)
Gene names: C20orf92, COMMD7
Sequence domains: COMM domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 215.191Å b: 74.895Å c: 63.632Å
α: 90° β: 96.397° γ: 90°
R-values:
R R work R free
0.242 0.238 0.278
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The PDLIM family of actin-associated proteins and their emerging role in membrane trafficking.
Healy et al. (2023)
2 other articles

1 mention without citation

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Healy et al. (2023)