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Crystal structure of COMMD7-COMMD9-COMMD5-COMMD10 tetramer

X-ray diffraction
3.33Å resolution
PDB entry 8esd coloured by chain, front view.
PDB entry 8esd coloured by chain, side view.
PDB entry 8esd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 27645.34 Å2
Buried surface area: 12222.4 Å2
Dissociation area: 1,779.91 Å2
Dissociation energy (ΔGdiss): 12.31 kcal/mol
Dissociation entropy (TΔSdiss): 13.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-275046

Macromolecules

COMM domain-containing protein 10
Chain: T
Length: 191 amino acids
Theoretical weight: 21.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6G5 (Residues: 12-202; Coverage: 95%)
Gene names: COMMD10, HSPC305, PTD002
Pfam:
COMM domain-containing protein 10 in PDB entry 8esd, assembly 1, front view.
COMM domain-containing protein 10 in PDB entry 8esd, assembly 1, side view.
COMM domain-containing protein 10 in PDB entry 8esd, assembly 1, top view.
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COMM domain-containing protein 9
Chain: N
Length: 194 amino acids
Theoretical weight: 21.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P000 (Residues: 5-198; Coverage: 98%)
Gene names: COMMD9, HSPC166
Pfam:
COMM domain-containing protein 9 in PDB entry 8esd, assembly 1, front view.
COMM domain-containing protein 9 in PDB entry 8esd, assembly 1, side view.
COMM domain-containing protein 9 in PDB entry 8esd, assembly 1, top view.
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COMM domain-containing protein 5
Chain: F
Length: 75 amino acids
Theoretical weight: 8.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZQ3 (Residues: 149-222; Coverage: 33%)
Gene names: COMMD5, HT002
Pfam: COMM domain
COMM domain-containing protein 5 in PDB entry 8esd, assembly 1, front view.
COMM domain-containing protein 5 in PDB entry 8esd, assembly 1, side view.
COMM domain-containing protein 5 in PDB entry 8esd, assembly 1, top view.
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COMM domain-containing protein 7
Chain: S
Length: 70 amino acids
Theoretical weight: 8.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86VX2 (Residues: 131-200; Coverage: 35%)
Gene names: C20orf92, COMMD7
Pfam: COMM domain
COMM domain-containing protein 7 in PDB entry 8esd, assembly 1, front view.
COMM domain-containing protein 7 in PDB entry 8esd, assembly 1, side view.
COMM domain-containing protein 7 in PDB entry 8esd, assembly 1, top view.
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