PDB 8esw structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)

Biochemical function:

NADH dehydrogenase (ubiquinone) activity

Biological process:

mitochondrial electron transport, NADH to ubiquinone

Cellular component:

mitochondrial inner membrane

Sequence domains:

78 more domains

Structure analysis Details

Assembly composition:

hetero 43-mer (preferred)

PDBe Complex ID:

PDB-CPX-108616 (preferred)

Entry contents:

42 distinct polypeptide molecules

Macromolecules (42 distinct):

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Chain: AN

Molecule details ›

Chain: AN
Length: 142 amino acids
Theoretical weight: 16.85 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VQD7 (Residues: 1-142; Coverage: 100%)

Gene names: B17.2, BcDNA:GH12382, CG3214, Dmel\CG3214, Dmel_CG3214, N7BM, ND-B17.2, Q9VQD7, anon-EST:Posey62, dNDUFA12
Sequence domains: NADH ubiquinone oxidoreductase subunit NDUFA12

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Chain: S6

Molecule details ›

Chain: S6
Length: 126 amino acids
Theoretical weight: 14.38 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VMU0 (Residues: 1-126; Coverage: 100%)

Gene names: CG8680, Dmel\CG8680, Dmel_CG8680, ND-13A, NUMM, dNDUFS6
Sequence domains: Zinc-finger domain

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Chain: S1

Molecule details ›

Chain: S1
Length: 731 amino acids
Theoretical weight: 78.72 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q94511 (Residues: 1-731; Coverage: 100%)

Gene names: CG2286, ND-75, ND75
Sequence domains:

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Chain: S3

Molecule details ›

Chain: S3
Length: 265 amino acids
Theoretical weight: 30.01 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VZU4 (Residues: 1-265; Coverage: 100%)

Gene names: CG12079, ND-30, NDUFS3
Sequence domains: Respiratory-chain NADH dehydrogenase, 30 Kd subunit

NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform B Chain: V2

Molecule details ›

Chain: V2
Length: 242 amino acids
Theoretical weight: 26.81 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VX36 (Residues: 1-242; Coverage: 100%)

Gene names: BEST:LP01573, CG 5703, CG5703, Dmel\CG5703, Dmel_CG5703, ND-24, NUHM, Ndufv2
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin

NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein Chain: S7

Molecule details ›

Chain: S7
Length: 221 amino acids
Theoretical weight: 24.62 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VXK7 (Residues: 1-221; Coverage: 100%)

Gene names: 20 kDa, CG9172, Dmel\CG9172, Dmel_CG9172, ND-20, NUKM, PSST, dNDUFS7
Sequence domains: NADH ubiquinone oxidoreductase, 20 Kd subunit

NADH dehydrogenase (ubiquinone) 23 kDa subunit Chain: S8

Molecule details ›

Chain: S8
Length: 217 amino acids
Theoretical weight: 24.61 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VF27 (Residues: 1-217; Coverage: 100%)

Gene names: CG3944, ND-23, NUIM, dNDUFS8
Sequence domains: 4Fe-4S dicluster domain

NADH-ubiquinone oxidoreductase chain 3 Chain: 3

Molecule details ›

Chain: 3
Length: 117 amino acids
Theoretical weight: 13.57 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P18930 (Residues: 1-117; Coverage: 100%)

Gene names: ND3, mt:ND3
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

NADH-ubiquinone oxidoreductase chain 1 Chain: 1

Molecule details ›

Chain: 1
Length: 315 amino acids
Theoretical weight: 36.38 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: C7DZL9 (Residues: 1-315; Coverage: 100%)

Gene name: ND1
Sequence domains: NADH dehydrogenase

NADH-ubiquinone oxidoreductase chain 4 Chain: 4

Molecule details ›

Chain: 4
Length: 446 amino acids
Theoretical weight: 51.38 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9MDK5 (Residues: 1-446; Coverage: 100%)

Gene names: CG34085, NADH4, ND4, mt:ND4, nad4
Sequence domains:

NADH-ubiquinone oxidoreductase chain 5 Chain: 5

Molecule details ›

Chain: 5
Length: 577 amino acids
Theoretical weight: 65.78 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: C7DZL4 (Residues: 1-577; Coverage: 100%)

Gene name: ND5
Sequence domains:

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Chain: A8

Molecule details ›

Chain: A8
Length: 175 amino acids
Theoretical weight: 19.87 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: B3DML8 (Residues: 26-200; Coverage: 88%)

Gene name: CG3683-RA
Sequence domains: CHCH domain

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Chain: A1

Molecule details ›

Chain: A1
Length: 123 amino acids
Theoretical weight: 14.88 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: A8DYC4 (Residues: 1-123; Coverage: 100%)

Gene names: BcDNA:RH49308, CG13328, CG17054, CG30057, CG34439, Dmel\CG34439, Dmel_CG34439, ND-MWFE, l(2)c00093
Sequence domains: NADH-ubiquinone oxidoreductase MWFE subunit

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Chain: AO

Molecule details ›

Chain: AO
Length: 154 amino acids
Theoretical weight: 17.77 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9W402 (Residues: 1-154; Coverage: 100%)

Gene names: CG3446, Dmel\CG3446, Dmel_CG3446, NB6M, ND-B16.6
Sequence domains: GRIM-19 protein

NADH dehydrogenase (Ubiquinone) 15 kDa subunit, isoform J Chain: S5

Molecule details ›

Chain: S5
Length: 101 amino acids
Theoretical weight: 12.02 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q7K1C0 (Residues: 1-101; Coverage: 100%)

Gene names: CG11455, CG11455-RB, CG3436, Dmel\CG11455, Dmel_CG11455, ND-15, NIPM, dNDUFS5
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Chain: AM

Molecule details ›

Chain: AM
Length: 170 amino acids
Theoretical weight: 18.43 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q7JYH3 (Residues: 1-170; Coverage: 100%)

Gene names: BcDNA:RH51452, CG9350, Dmel\CG9350, Dmel_CG9350, ND-B14.7

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Chain: BL

Molecule details ›

Chain: BL
Length: 159 amino acids
Theoretical weight: 18.95 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VQR2 (Residues: 1-159; Coverage: 100%)

Gene names: BcDNA:RE65754, CG8844, Dmel\CG8844, Dmel_CG8844, ND-PDSW, NIDM, PDSW, Pdsw, Q9VQR2, anon-EST:Posey91, dNDUFB10, l(2)k10101, pdsw
Sequence domains: NADH-ubiquinone oxidoreductase subunit 10

NADH dehydrogenase (Ubiquinone) B17 subunit, isoform A Chain: B6

Molecule details ›

Chain: B6
Length: 167 amino acids
Theoretical weight: 19.03 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9V3W2 (Residues: 1-167; Coverage: 100%)

Gene names: BG:DS09217.1, BcDNA:GM23292, CG13240, Dmel\CG13240, Dmel_CG13240, NB7M, ND-B17, dNDUFB6, l(2)35Di
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Chain: B4

Molecule details ›

Chain: B4
Length: 113 amino acids
Theoretical weight: 13.16 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q6IDF5 (Residues: 1-113; Coverage: 100%)

Gene names: CG 12859, CG12859, Dmel\CG12859, Dmel_CG12859, NB5M, ND-B15, anon-EST:fe3B12
Sequence domains: NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Chain: B7

Molecule details ›

Chain: B7
Length: 117 amino acids
Theoretical weight: 13.91 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VXZ0 (Residues: 1-117; Coverage: 100%)

Gene names: CG5548, Dmel\CG5548, Dmel_CG5548, NB8M, ND-B18
Sequence domains: NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Chain: B5

Molecule details ›

Chain: B5
Length: 186 amino acids
Theoretical weight: 22.07 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VTU2 (Residues: 1-186; Coverage: 100%)

Gene names: CG9762, Dmel\CG9762, Dmel_CG9762, ND-SGDH, NISM, Q9VTU2, dND-SGDH, dNDUFB5, l(3)neo18
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Chain: B9

Molecule details ›

Chain: B9
Length: 144 amino acids
Theoretical weight: 17.42 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VJZ4 (Residues: 1-144; Coverage: 100%)

Gene names: CG9306, Dmel\CG9306, Dmel_CG9306, ND-B22, NI2M, Ndufb9, Q9VJZ4, dNDUFB9
Sequence domains: Complex 1 protein (LYR family)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Chain: BM

Molecule details ›

Chain: BM
Length: 150 amino acids
Theoretical weight: 16.99 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9V3L7 (Residues: 1-150; Coverage: 100%)

Gene names: CG6008, Dmel\CG6008, Dmel_CG6008, NP15.6, anon-WO0118547.281
Sequence domains: ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Chain: B8

Molecule details ›

Chain: B8
Length: 175 amino acids
Theoretical weight: 20.23 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9W3X7 (Residues: 1-175; Coverage: 100%)

Gene names: CG3192, CG3192-RA, Dmel\CG3192, Dmel_CG3192, ND-ASHI, NIAM
Sequence domains: NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Chain: B3

Molecule details ›

Chain: B3
Length: 110 amino acids
Theoretical weight: 12.11 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9W2E8 (Residues: 1-110; Coverage: 100%)

Gene names: 10320, CG10320, Dmel\CG10320, Dmel_CG10320, NB2M, ND-B12, anon-EST:Posey47, anon-EST:Posey84
Sequence domains: NADH-ubiquinone oxidoreductase B12 subunit family

Acyl carrier protein, mitochondrial Chains: AB, AC

Molecule details ›

Chains: AB, AC
Length: 152 amino acids
Theoretical weight: 17.26 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q94519 (Residues: 1-152; Coverage: 100%)

Gene names: CG9160, ND-ACP, ND-AcC, mtACP, mtacp1
Sequence domains: Phosphopantetheine attachment site

NADH dehydrogenase [ubiquinone] 1 subunit C2 Chain: C2

Molecule details ›

Chain: C2
Length: 116 amino acids
Theoretical weight: 12.93 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VQM2 (Residues: 1-116; Coverage: 100%)

Gene names: BcDNA:RE29623, CG12400, Dmel\CG12400, Dmel_CG12400, N4BM, ND-B14.5B, Q9VQM2, dNDUFC2
Sequence domains: NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Chain: B1

Molecule details ›

Chain: B1
Length: 56 amino acids
Theoretical weight: 6.23 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9W3N7 (Residues: 1-56; Coverage: 100%)

Gene names: CG15328, CG18624, CG18624-RA, CG18624-RB, Dmel\CG18624, Dmel_CG18624, ND-MNLL, NINM
Sequence domains: MNLL subunit

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Chain: S4

Molecule details ›

Chain: S4
Length: 183 amino acids
Theoretical weight: 20.71 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VWI0 (Residues: 1-183; Coverage: 100%)

Gene names: CG12203, ND-18, NUYM, dNDUFS4
Sequence domains: NADH dehydrogenase ubiquinone Fe-S protein 4

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Chain: A9

Molecule details ›

Chain: A9
Length: 416 amino acids
Theoretical weight: 46.89 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VPE2 (Residues: 1-416; Coverage: 100%)

Gene names: CG6020, CG6020-RA, Dmel\CG6020, Dmel_CG6020, GM13757p, ND-39, NDUFA9, NUEM, Ndufa9, dNDUFA9
Sequence domains: NAD dependent epimerase/dehydratase family

GEO11417p1 Chain: B2

Molecule details ›

Chain: B2
Length: 94 amino acids
Theoretical weight: 10.76 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q7PL91 (Residues: 1-94; Coverage: 100%)

Gene names: CG40002, CG40472, CR40472, Dmel\CG40002, Dmel\CG40472, Dmel_CG40002, Dmel_CG40472, ND-AGGG, ND-AGGGL, dNDUFB2A, dNDUFB2B, l7A
Sequence domains: NADH dehydrogenase 1 beta subcomplex subunit 2

Complex I-49kD Chain: S2

Molecule details ›

Chain: S2
Length: 468 amino acids
Theoretical weight: 52.99 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9V4E0 (Residues: 1-468; Coverage: 100%)

Gene names: CG 1970, CG1970, CG1970-RA, Dmel\CG1970, Dmel_CG1970, ND-49, NUCM, Ndufs2
Sequence domains: Respiratory-chain NADH dehydrogenase, 49 Kd subunit

NADH dehydrogenase [ubiquinone] flavoprotein 3 Chain: V3

Molecule details ›

Chain: V3
Length: 27 amino acids
Theoretical weight: 2.32 KDa
Source organism: Drosophila melanogaster

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Chain: V1

Molecule details ›

Chain: V1
Length: 474 amino acids
Theoretical weight: 51.9 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VMI3 (Residues: 1-474; Coverage: 100%)

Gene names: CG9140, Dmel\CG9140, Dmel_CG9140, ND-51, ND51, NDUFV1, NUBM, dNDUFV1, dNDUFV1A
Sequence domains:

NADH-ubiquinone oxidoreductase chain 2 Chain: 2

Molecule details ›

Chain: 2
Length: 341 amino acids
Theoretical weight: 39.84 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P03896 (Residues: 1-341; Coverage: 100%)

Gene names: NADH2, ND2, mt:ND2
Sequence domains:

NADH-ubiquinone oxidoreductase chain 4L Chain: 4L

Molecule details ›

Chain: 4L
Length: 96 amino acids
Theoretical weight: 11.36 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P18934 (Residues: 1-96; Coverage: 100%)

Gene names: ND4L, mt:ND4L
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L

NADH-ubiquinone oxidoreductase chain 6 Chain: 6

Molecule details ›

Chain: 6
Length: 174 amino acids
Theoretical weight: 20.08 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: P18933 (Residues: 1-174; Coverage: 100%)

Gene names: ND6, mt:ND6
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 6

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Chain: A7

Molecule details ›

Chain: A7
Length: 103 amino acids
Theoretical weight: 11.56 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: O97418 (Residues: 1-103; Coverage: 100%)

Gene names: 152A3.7, BcDNA:RE75088, CG3621, CG3621-RA, Dmel\CG3621, Dmel_CG3621, EG:152A3.7, N4AM, ND-B14.5A, RNAA, anon-2D, anon-2Db
Sequence domains: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)

RH11203p Chain: A5

Molecule details ›

Chain: A5
Length: 124 amino acids
Theoretical weight: 13.81 KDa
Source organism: Drosophila melanogaster
UniProt:

Canonical: Q9VTB4 (Residues: 1-124; Coverage: 100%)

Gene names: BcDNA:RH11203, CG6463, Dmel\CG6463, Dmel_CG6463, ND-13B, NUFM, Q9VTB4, dNDUFA5
Sequence domains: ETC complex I subunit conserved region

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Chain: A3

Molecule details ›

Chain: A3
Length: 77 amino acids
Theoretical weight: 8.41 KDa
Source organism: Drosophila melanogaster
UniProt: