Structure analysis

Dual Modulators

X-ray diffraction
2.01Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 11087.93 Å2
Buried surface area: 1039.61 Å2
Dissociation area: 519.81 Å2
Dissociation energy (ΔGdiss): 2.77 kcal/mol
Dissociation entropy (TΔSdiss): 6.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136916
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 11085.83 Å2
Buried surface area: 856.93 Å2
Dissociation area: 428.47 Å2
Dissociation energy (ΔGdiss): 5.25 kcal/mol
Dissociation entropy (TΔSdiss): 6.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136916

Macromolecules

Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03372 (Residues: 298-554; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:

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Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

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