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Human CCC complex

Electron Microscopy
3.12Å resolution
PDB entry 8f2r coloured by chain, front view.
PDB entry 8f2r coloured by chain, side view.
PDB entry 8f2r coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero decamer (preferred)
Entry contents: 10 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero decamer
Accessible surface area: 90293.77 Å2
Buried surface area: 38705.49 Å2
Dissociation area: 2,744.5 Å2
Dissociation energy (ΔGdiss): 14.06 kcal/mol
Dissociation entropy (TΔSdiss): 15.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-216421

Macromolecules

COMM domain-containing protein 1
Chain: A
Length: 187 amino acids
Theoretical weight: 20.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q8N668 (Residues: 1-187; Coverage: 98%)
Gene names: C2orf5, COMMD1, MURR1
Pfam:
COMM domain-containing protein 1 in PDB entry 8f2r, assembly 1, front view.
COMM domain-containing protein 1 in PDB entry 8f2r, assembly 1, side view.
COMM domain-containing protein 1 in PDB entry 8f2r, assembly 1, top view.
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COMM domain-containing protein 2
Chain: B
Length: 199 amino acids
Theoretical weight: 22.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q86X83 (Residues: 1-199; Coverage: 100%)
Gene names: COMMD2, HSPC042, My004
Pfam:
COMM domain-containing protein 2 in PDB entry 8f2r, assembly 1, front view.
COMM domain-containing protein 2 in PDB entry 8f2r, assembly 1, side view.
COMM domain-containing protein 2 in PDB entry 8f2r, assembly 1, top view.
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COMM domain-containing protein 3
Chain: C
Length: 195 amino acids
Theoretical weight: 22.18 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9UBI1 (Residues: 1-195; Coverage: 100%)
Gene names: BUP, C10orf8, COMMD3
Pfam:
COMM domain-containing protein 3 in PDB entry 8f2r, assembly 1, front view.
COMM domain-containing protein 3 in PDB entry 8f2r, assembly 1, side view.
COMM domain-containing protein 3 in PDB entry 8f2r, assembly 1, top view.
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COMM domain-containing protein 4
Chain: D
Length: 199 amino acids
Theoretical weight: 21.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9H0A8 (Residues: 1-199; Coverage: 100%)
Gene name: COMMD4
Pfam:
COMM domain-containing protein 4 in PDB entry 8f2r, assembly 1, front view.
COMM domain-containing protein 4 in PDB entry 8f2r, assembly 1, side view.
COMM domain-containing protein 4 in PDB entry 8f2r, assembly 1, top view.
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COMM domain-containing protein 5
Chain: E
Length: 205 amino acids
Theoretical weight: 22.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9GZQ3 (Residues: 20-224; Coverage: 92%)
Gene names: COMMD5, HT002
Pfam:
COMM domain-containing protein 5 in PDB entry 8f2r, assembly 1, front view.
COMM domain-containing protein 5 in PDB entry 8f2r, assembly 1, side view.
COMM domain-containing protein 5 in PDB entry 8f2r, assembly 1, top view.
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COMM domain-containing protein 6
Chain: F
Length: 77 amino acids
Theoretical weight: 8.82 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q7Z4G1 (Residues: 9-85; Coverage: 91%)
Gene names: COMMD6, MSTP076
Pfam: COMM domain
COMM domain-containing protein 6 in PDB entry 8f2r, assembly 1, front view.
COMM domain-containing protein 6 in PDB entry 8f2r, assembly 1, side view.
COMM domain-containing protein 6 in PDB entry 8f2r, assembly 1, top view.
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COMM domain-containing protein 7
Chain: G
Length: 200 amino acids
Theoretical weight: 22.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q86VX2 (Residues: 1-200; Coverage: 100%)
Gene names: C20orf92, COMMD7
Pfam:
COMM domain-containing protein 7 in PDB entry 8f2r, assembly 1, front view.
COMM domain-containing protein 7 in PDB entry 8f2r, assembly 1, side view.
COMM domain-containing protein 7 in PDB entry 8f2r, assembly 1, top view.
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COMM domain-containing protein 8
Chain: H
Length: 179 amino acids
Theoretical weight: 20.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9NX08 (Residues: 5-183; Coverage: 98%)
Gene names: COMMD8, MDS022
Pfam:
COMM domain-containing protein 8 in PDB entry 8f2r, assembly 1, front view.
COMM domain-containing protein 8 in PDB entry 8f2r, assembly 1, side view.
COMM domain-containing protein 8 in PDB entry 8f2r, assembly 1, top view.
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COMM domain-containing protein 9
Chain: I
Length: 198 amino acids
Theoretical weight: 21.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9P000 (Residues: 1-198; Coverage: 100%)
Gene names: COMMD9, HSPC166
Pfam:
COMM domain-containing protein 9 in PDB entry 8f2r, assembly 1, front view.
COMM domain-containing protein 9 in PDB entry 8f2r, assembly 1, side view.
COMM domain-containing protein 9 in PDB entry 8f2r, assembly 1, top view.
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COMM domain-containing protein 10
Chain: J
Length: 198 amino acids
Theoretical weight: 22.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9Y6G5 (Residues: 5-202; Coverage: 98%)
Gene names: COMMD10, HSPC305, PTD002
Pfam:
COMM domain-containing protein 10 in PDB entry 8f2r, assembly 1, front view.
COMM domain-containing protein 10 in PDB entry 8f2r, assembly 1, side view.
COMM domain-containing protein 10 in PDB entry 8f2r, assembly 1, top view.
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