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LRRC8A(T48D):C conformation 2 top focus

Electron Microscopy
3.1Å resolution
PDB entry 8f74 coloured by chain, front view.
PDB entry 8f74 coloured by chain, side view.
PDB entry 8f74 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Volume-regulated anion channel
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Multimeric state: hetero hexamer
Accessible surface area: 77594.49 Å2
Buried surface area: 29683.51 Å2
Dissociation area: 3,594.67 Å2
Dissociation energy (ΔGdiss): 37.86 kcal/mol
Dissociation entropy (TΔSdiss): 15.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-142120

Macromolecules

Soluble cytochrome b562; Volume-regulated anion channel subunit LRRC8A
Chains: A, B, C, D, E
Length: 911 amino acids
Theoretical weight: 105.54 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q80WG5 (Residues: 1-76, 92-810; Coverage: 98%)
  • Canonical: P0ABE7 (Residues: 23-127; Coverage: 99%)
    • nullnull
Gene names: Lrrc8, Lrrc8a, cybC
Pfam:
InterPro:
Soluble cytochrome b562 in PDB entry 8f74, assembly 1, front view.
Soluble cytochrome b562 in PDB entry 8f74, assembly 1, side view.
Soluble cytochrome b562 in PDB entry 8f74, assembly 1, top view.
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Volume-regulated anion channel subunit LRRC8C
Chain: F
Length: 813 amino acids
Theoretical weight: 93.62 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8R502 (Residues: 1-803; Coverage: 100%)
Gene names: Ad158, Fad158, Lrrc8c
Pfam:
InterPro:
Volume-regulated anion channel subunit LRRC8C in PDB entry 8f74, assembly 1, front view.
Volume-regulated anion channel subunit LRRC8C in PDB entry 8f74, assembly 1, side view.
Volume-regulated anion channel subunit LRRC8C in PDB entry 8f74, assembly 1, top view.
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