Structure analysis

Macrocyclic Plasmin Inhibitor

X-ray diffraction
1.47Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: monomeric
Accessible surface area: 10612.71 Å2
Buried surface area: 240.14 Å2
Dissociation area: 47.67 Å2
Dissociation energy (ΔGdiss): 6.05 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133230
Assembly 2 (preferred)
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Multimeric state: monomeric
Accessible surface area: 11969.1 Å2
Buried surface area: 583.49 Å2
Dissociation area: 6.01 Å2
Dissociation energy (ΔGdiss): 0.26 kcal/mol
Dissociation entropy (TΔSdiss): 0.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133230

Macromolecules

Chains: A, B
Length: 250 amino acids
Theoretical weight: 27.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P00747 (Residues: 561-810; Coverage: 32%)
Gene name: PLG
Pfam: Trypsin
InterPro:
PDBe-KB: UniProt Coverage View: P00747  
125020406080100120140160180200220240
 
100200
UniProt
P00747
PRO_0000028054
PRO_0000028056
PRO_0000028058
Chains
Domains
Secondary structure
Ligand binding sites

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