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Asymmetric structure of cleaved HIV-1 AD8 envelope glycoprotein trimer in styrene-maleic acid lipid nanoparticles

Electron Microscopy
4Å resolution
PDB entry 8fad coloured by chain, front view.
PDB entry 8fad coloured by chain, side view.
PDB entry 8fad coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transmembrane protein gp41 and Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein
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Multimeric state: hetero hexamer
Accessible surface area: 98569.29 Å2
Buried surface area: 54104.19 Å2
Dissociation area: 1,290.08 Å2
Dissociation energy (ΔGdiss): -64.17 kcal/mol
Dissociation entropy (TΔSdiss): 39.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-275640

Macromolecules

Transmembrane protein gp41
Chains: B, D, F
Length: 138 amino acids
Theoretical weight: 15.67 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A120K6L5 (Residues: 514-651; Coverage: 16%)
Gene name: env
Pfam: Retroviral envelope protein
Transmembrane protein gp41 in PDB entry 8fad, assembly 1, front view.
Transmembrane protein gp41 in PDB entry 8fad, assembly 1, side view.
Transmembrane protein gp41 in PDB entry 8fad, assembly 1, top view.
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Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein
Chains: A, C, E
Length: 469 amino acids
Theoretical weight: 52.78 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: B0FDK7 (Residues: 33-501; Coverage: 92%)
Gene name: env
Pfam: Envelope glycoprotein GP120
Envelope glycoprotein gp120 in PDB entry 8fad, assembly 1, front view.
Envelope glycoprotein gp120 in PDB entry 8fad, assembly 1, side view.
Envelope glycoprotein gp120 in PDB entry 8fad, assembly 1, top view.
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