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Electron Microscopy
3.47Å resolution

Cryo-EM structure of the human TRPV4 in complex with GSK1016790A

Released:
Source organism: Homo sapiens
Related structures: EMD-28976

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
PDBe Complex ID:
PDB-CPX-221491 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 901 amino acids
Theoretical weight: 102.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HBA0 (Residues: 1-871; Coverage: 100%)
Gene names: TRPV4, VRL2, VROAC
Sequence domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.47Å
Relevant EMDB volumes: EMD-28976
Expression system: Homo sapiens