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Cryo-EM structure of human NCC (class 1)

Source organism: Danio rerio
Biochemical function: transmembrane transporter activity
Biological process: transmembrane transport
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF03522
Domain description: Solute carrier family 12
Occurring in:
  1. Solute carrier family 12 member 3
The deposited structure of PDB entry 8fho contains 6 copies of Pfam domain PF03522 (Solute carrier family 12) in Solute carrier family 12 member 3. Showing 2 copies in chain A.

PF00324
Domain description: Amino acid permease
Occurring in:
  1. Solute carrier family 12 member 3
The deposited structure of PDB entry 8fho contains 3 copies of Pfam domain PF00324 (Amino acid permease) in Solute carrier family 12 member 3. Showing 1 copy in chain A.

PF08403
Domain description: Amino acid permease N-terminal
Occurring in:
  1. Solute carrier family 12 member 3
The deposited structure of PDB entry 8fho contains 3 copies of Pfam domain PF08403 (Amino acid permease N-terminal) in Solute carrier family 12 member 3. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR002948
Domain description: Thiazide-sensitive Na-K-Cl co-transporter
Occurring in:
  1. Solute carrier family 12 member 3
IPR018491
Domain description: SLC12A transporter, C-terminal
Occurring in:
  1. Solute carrier family 12 member 3
IPR004842
Domain description: SLC12A transporter family
Occurring in:
  1. Solute carrier family 12 member 3
IPR004841
Domain description: Amino acid permease/ SLC12A domain
Occurring in:
  1. Solute carrier family 12 member 3
IPR013612
Domain description: Amino acid permease, N-terminal
Occurring in:
  1. Solute carrier family 12 member 3

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