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Human nucleolar pre-60S ribosomal subunit (State F)

Electron Microscopy
2.67Å resolution
PDB entry 8fky coloured by chain, front view.
PDB entry 8fky coloured by chain, side view.
PDB entry 8fky coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero 59-mer (preferred)
Entry contents: 56 distinct polypeptide molecules
3 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 59-mer
Accessible surface area: 870474.15 Å2
Buried surface area: 431437.35 Å2
Dissociation area: 1,351.84 Å2
Dissociation energy (ΔGdiss): 6.73 kcal/mol
Dissociation entropy (TΔSdiss): 15.4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-221156

Macromolecules

Large ribosomal subunit protein uL11
Chain: BA
Length: 165 amino acids
Theoretical weight: 17.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P30050 (Residues: 1-165; Coverage: 100%)
Gene name: RPL12
Pfam:
Large ribosomal subunit protein uL11 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL11 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL11 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL1
Chain: BB
Length: 217 amino acids
Theoretical weight: 24.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62906 (Residues: 1-217; Coverage: 100%)
Gene names: NEDD6, RPL10A
Pfam: Ribosomal protein L1p/L10e family
Large ribosomal subunit protein uL1 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL1 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL1 in PDB entry 8fky, assembly 1, top view.
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WD repeat-containing protein 55
Chain: BC
Length: 383 amino acids
Theoretical weight: 42.12 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H6Y2 (Residues: 1-383; Coverage: 100%)
Gene name: WDR55
Pfam:
WD repeat-containing protein 55 in PDB entry 8fky, assembly 1, front view.
WD repeat-containing protein 55 in PDB entry 8fky, assembly 1, side view.
WD repeat-containing protein 55 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL13
Chain: L6
Length: 211 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P26373 (Residues: 1-211; Coverage: 100%)
Gene names: BBC1, OK/SW-cl.46, RPL13
Pfam: Ribosomal protein L13e
Large ribosomal subunit protein eL13 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL13 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL13 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL13
Chain: L7
Length: 203 amino acids
Theoretical weight: 23.63 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P40429 (Residues: 1-203; Coverage: 100%)
Gene name: RPL13A
Pfam: Ribosomal protein L13
Large ribosomal subunit protein uL13 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL13 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL13 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL14
Chain: L8
Length: 215 amino acids
Theoretical weight: 23.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P50914 (Residues: 1-215; Coverage: 100%)
Gene name: RPL14
Pfam: Ribosomal protein L14
Large ribosomal subunit protein eL14 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL14 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL14 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL15
Chain: L9
Length: 204 amino acids
Theoretical weight: 24.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61313 (Residues: 1-204; Coverage: 100%)
Gene names: EC45, RPL15, TCBAP0781
Pfam: Ribosomal L15
Large ribosomal subunit protein eL15 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL15 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL15 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL22
Chain: LA
Length: 184 amino acids
Theoretical weight: 21.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18621 (Residues: 1-184; Coverage: 100%)
Gene name: RPL17
Pfam: Ribosomal protein L22p/L17e
Large ribosomal subunit protein uL22 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL22 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL22 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL18
Chain: LB
Length: 188 amino acids
Theoretical weight: 21.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q07020 (Residues: 1-188; Coverage: 100%)
Gene name: RPL18
Pfam: Ribosomal protein 60S L18 and 50S L18e
Large ribosomal subunit protein eL18 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL18 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL18 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL20
Chain: LC
Length: 176 amino acids
Theoretical weight: 20.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q02543 (Residues: 1-176; Coverage: 100%)
Gene name: RPL18A
Pfam: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
Large ribosomal subunit protein eL20 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL20 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL20 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL19
Chain: LD
Length: 196 amino acids
Theoretical weight: 23.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P84098 (Residues: 1-196; Coverage: 100%)
Gene name: RPL19
Pfam: Ribosomal protein L19e
Large ribosomal subunit protein eL19 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL19 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL19 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL21
Chain: LE
Length: 160 amino acids
Theoretical weight: 18.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46778 (Residues: 1-160; Coverage: 100%)
Gene name: RPL21
Pfam: Ribosomal protein L21e
Large ribosomal subunit protein eL21 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL21 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL21 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL14
Chain: LG
Length: 140 amino acids
Theoretical weight: 14.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62829 (Residues: 1-140; Coverage: 100%)
Gene name: RPL23
Pfam: Ribosomal protein L14p/L23e
Large ribosomal subunit protein uL14 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL14 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL14 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL23
Chain: LH
Length: 156 amino acids
Theoretical weight: 17.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62750 (Residues: 1-156; Coverage: 100%)
Gene name: RPL23A
Pfam:
Large ribosomal subunit protein uL23 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL23 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL23 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL24
Chain: LI
Length: 145 amino acids
Theoretical weight: 17.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61254 (Residues: 1-145; Coverage: 100%)
Gene name: RPL26
Pfam:
Large ribosomal subunit protein uL24 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL24 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL24 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL27
Chain: LJ
Length: 136 amino acids
Theoretical weight: 15.84 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61353 (Residues: 1-136; Coverage: 100%)
Gene name: RPL27
Pfam:
Large ribosomal subunit protein eL27 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL27 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL27 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL15
Chain: LK
Length: 148 amino acids
Theoretical weight: 16.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46776 (Residues: 1-148; Coverage: 100%)
Gene name: RPL27A
Pfam: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Large ribosomal subunit protein uL15 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL15 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL15 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL28
Chain: LL
Length: 137 amino acids
Theoretical weight: 15.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46779 (Residues: 1-137; Coverage: 100%)
Gene name: RPL28
Pfam: Ribosomal L28e protein family
Large ribosomal subunit protein eL28 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL28 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL28 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL3
Chain: LN
Length: 403 amino acids
Theoretical weight: 46.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P39023 (Residues: 1-403; Coverage: 100%)
Gene names: OK/SW-cl.32, RPL3
Pfam: Ribosomal protein L3
Large ribosomal subunit protein uL3 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL3 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL3 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL30
Chain: LO
Length: 115 amino acids
Theoretical weight: 12.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62888 (Residues: 1-115; Coverage: 100%)
Gene name: RPL30
Pfam: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL30 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL30 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL30 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL31
Chain: LP
Length: 125 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62899 (Residues: 1-125; Coverage: 100%)
Gene name: RPL31
Pfam: Ribosomal protein L31e
Large ribosomal subunit protein eL31 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL31 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL31 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL32
Chain: LQ
Length: 135 amino acids
Theoretical weight: 15.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62910 (Residues: 1-135; Coverage: 100%)
Gene names: PP9932, RPL32
Pfam: Ribosomal protein L32
Large ribosomal subunit protein eL32 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL32 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL32 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL34
Chain: LR
Length: 117 amino acids
Theoretical weight: 13.33 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49207 (Residues: 1-117; Coverage: 100%)
Gene name: RPL34
Pfam: Ribosomal protein L34e
Large ribosomal subunit protein eL34 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL34 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL34 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL29
Chain: LS
Length: 123 amino acids
Theoretical weight: 14.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P42766 (Residues: 1-123; Coverage: 100%)
Gene name: RPL35
Pfam: Ribosomal L29 protein
Large ribosomal subunit protein uL29 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL29 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL29 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL33
Chain: LT
Length: 110 amino acids
Theoretical weight: 12.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18077 (Residues: 1-110; Coverage: 100%)
Gene names: GIG33, RPL35A
Pfam: Ribosomal protein L35Ae
Large ribosomal subunit protein eL33 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL33 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL33 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL36
Chain: LU
Length: 105 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3U8 (Residues: 1-105; Coverage: 100%)
Gene name: RPL36
Pfam: Ribosomal protein L36e
Large ribosomal subunit protein eL36 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL36 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL36 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL37
Chain: LW
Length: 97 amino acids
Theoretical weight: 11.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61927 (Residues: 1-97; Coverage: 100%)
Gene name: RPL37
Pfam: Ribosomal protein L37e
Large ribosomal subunit protein eL37 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL37 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL37 in PDB entry 8fky, assembly 1, top view.
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Nucleolar complex protein 2 homolog
Chain: NA
Length: 749 amino acids
Theoretical weight: 85.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3T9 (Residues: 1-749; Coverage: 100%)
Gene names: NIR, NOC2L
Pfam: Noc2p family
Nucleolar complex protein 2 homolog in PDB entry 8fky, assembly 1, front view.
Nucleolar complex protein 2 homolog in PDB entry 8fky, assembly 1, side view.
Nucleolar complex protein 2 homolog in PDB entry 8fky, assembly 1, top view.
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Guanine nucleotide-binding protein-like 3
Chain: NB
Length: 549 amino acids
Theoretical weight: 62.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BVP2 (Residues: 1-549; Coverage: 100%)
Gene names: E2IG3, GNL3, NS
Pfam:
Guanine nucleotide-binding protein-like 3 in PDB entry 8fky, assembly 1, front view.
Guanine nucleotide-binding protein-like 3 in PDB entry 8fky, assembly 1, side view.
Guanine nucleotide-binding protein-like 3 in PDB entry 8fky, assembly 1, top view.
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Ribosome biogenesis protein NSA2 homolog
Chain: NF
Length: 260 amino acids
Theoretical weight: 30.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95478 (Residues: 1-260; Coverage: 100%)
Gene names: HUSSY-29, NSA2, TINP1
Pfam: Ribosomal protein S8e
Ribosome biogenesis protein NSA2 homolog in PDB entry 8fky, assembly 1, front view.
Ribosome biogenesis protein NSA2 homolog in PDB entry 8fky, assembly 1, side view.
Ribosome biogenesis protein NSA2 homolog in PDB entry 8fky, assembly 1, top view.
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60S ribosome subunit biogenesis protein NIP7 homolog
Chain: NH
Length: 180 amino acids
Theoretical weight: 20.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y221 (Residues: 1-180; Coverage: 100%)
Gene names: CGI-37, HSPC031, HSPC180, NIP7, OK/SW-cl.76, OK/SW-cl.78
Pfam:
60S ribosome subunit biogenesis protein NIP7 homolog in PDB entry 8fky, assembly 1, front view.
60S ribosome subunit biogenesis protein NIP7 homolog in PDB entry 8fky, assembly 1, side view.
60S ribosome subunit biogenesis protein NIP7 homolog in PDB entry 8fky, assembly 1, top view.
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ATP-dependent RNA helicase DDX54
Chain: NI
Length: 881 amino acids
Theoretical weight: 98.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TDD1 (Residues: 1-881; Coverage: 100%)
  • Best match: Q8TDD1-2 (Residues: 1-882)
Gene name: DDX54
Pfam:
ATP-dependent RNA helicase DDX54 in PDB entry 8fky, assembly 1, front view.
ATP-dependent RNA helicase DDX54 in PDB entry 8fky, assembly 1, side view.
ATP-dependent RNA helicase DDX54 in PDB entry 8fky, assembly 1, top view.
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Protein LLP homolog
Chain: NK
Length: 129 amino acids
Theoretical weight: 15.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BRT6 (Residues: 1-129; Coverage: 100%)
Gene names: C12orf31, LLPH, cPERP-G
Pfam: LLP homolog
Protein LLP homolog in PDB entry 8fky, assembly 1, front view.
Protein LLP homolog in PDB entry 8fky, assembly 1, side view.
Protein LLP homolog in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL4
Chain: SA
Length: 427 amino acids
Theoretical weight: 47.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P36578 (Residues: 1-427; Coverage: 100%)
Gene names: RPL1, RPL4
Pfam:
Large ribosomal subunit protein uL4 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL4 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL4 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL6
Chain: SC
Length: 288 amino acids
Theoretical weight: 32.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q02878 (Residues: 1-288; Coverage: 100%)
Gene names: RPL6, TXREB1
Pfam:
Large ribosomal subunit protein eL6 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL6 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL6 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL30
Chain: SD
Length: 248 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18124 (Residues: 1-248; Coverage: 100%)
Gene name: RPL7
Pfam:
Large ribosomal subunit protein uL30 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL30 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL30 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein eL8
Chain: SE
Length: 266 amino acids
Theoretical weight: 30.06 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62424 (Residues: 1-266; Coverage: 100%)
Gene names: RPL7A, SURF-3, SURF3
Pfam: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Large ribosomal subunit protein eL8 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein eL8 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein eL8 in PDB entry 8fky, assembly 1, top view.
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Large ribosomal subunit protein uL6
Chain: SG
Length: 192 amino acids
Theoretical weight: 21.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P32969 (Residues: 1-192; Coverage: 100%)
Gene names: OK/SW-cl.103, RPL9, RPL9P7, RPL9P8, RPL9P9
Pfam: Ribosomal protein L6
Large ribosomal subunit protein uL6 in PDB entry 8fky, assembly 1, front view.
Large ribosomal subunit protein uL6 in PDB entry 8fky, assembly 1, side view.
Large ribosomal subunit protein uL6 in PDB entry 8fky, assembly 1, top view.
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MKI67 FHA domain-interacting nucleolar phosphoprotein
Chain: SH
Length: 293 amino acids
Theoretical weight: 34.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYG3 (Residues: 1-293; Coverage: 100%)
Gene names: MKI67IP, NIFK, NOPP34
Pfam:
MKI67 FHA domain-interacting nucleolar phosphoprotein in PDB entry 8fky, assembly 1, front view.
MKI67 FHA domain-interacting nucleolar phosphoprotein in PDB entry 8fky, assembly 1, side view.
MKI67 FHA domain-interacting nucleolar phosphoprotein in PDB entry 8fky, assembly 1, top view.
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Ribosomal protein uL30-like
Chain: SI
Length: 255 amino acids
Theoretical weight: 29.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6DKI1 (Residues: 1-255; Coverage: 100%)
Gene name: RPL7L1
Pfam:
Ribosomal protein uL30-like in PDB entry 8fky, assembly 1, front view.
Ribosomal protein uL30-like in PDB entry 8fky, assembly 1, side view.
Ribosomal protein uL30-like in PDB entry 8fky, assembly 1, top view.
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pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Chain: SJ
Length: 847 amino acids
Theoretical weight: 96.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8IY81 (Residues: 1-847; Coverage: 100%)
Gene names: FTSJ3, SB92
Pfam:
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 in PDB entry 8fky, assembly 1, front view.
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 in PDB entry 8fky, assembly 1, side view.
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 in PDB entry 8fky, assembly 1, top view.
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Eukaryotic translation initiation factor 6
Chain: SK
Length: 245 amino acids
Theoretical weight: 26.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P56537 (Residues: 1-245; Coverage: 100%)
Gene names: EIF3A, EIF6, ITGB4BP, OK/SW-cl.27
Pfam: eIF-6 family
Eukaryotic translation initiation factor 6 in PDB entry 8fky, assembly 1, front view.
Eukaryotic translation initiation factor 6 in PDB entry 8fky, assembly 1, side view.
Eukaryotic translation initiation factor 6 in PDB entry 8fky, assembly 1, top view.
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Ribosomal L1 domain-containing protein 1
Chain: SL
Length: 490 amino acids
Theoretical weight: 55.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O76021 (Residues: 1-490; Coverage: 100%)
Gene names: CATX11, CSIG, L12, PBK1, RSL1D1
Pfam: Ribosomal protein L1p/L10e family
Ribosomal L1 domain-containing protein 1 in PDB entry 8fky, assembly 1, front view.
Ribosomal L1 domain-containing protein 1 in PDB entry 8fky, assembly 1, side view.
Ribosomal L1 domain-containing protein 1 in PDB entry 8fky, assembly 1, top view.
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Pescadillo homolog
Chain: SM
Length: 588 amino acids
Theoretical weight: 68.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O00541 (Residues: 1-588; Coverage: 100%)
Gene name: PES1
Pfam:
Pescadillo homolog in PDB entry 8fky, assembly 1, front view.
Pescadillo homolog in PDB entry 8fky, assembly 1, side view.
Pescadillo homolog in PDB entry 8fky, assembly 1, top view.
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Probable rRNA-processing protein EBP2
Chain: SN
Length: 306 amino acids
Theoretical weight: 34.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q99848 (Residues: 1-306; Coverage: 100%)
Gene names: EBNA1BP2, EBP2
Pfam: Eukaryotic rRNA processing protein EBP2
Probable rRNA-processing protein EBP2 in PDB entry 8fky, assembly 1, front view.
Probable rRNA-processing protein EBP2 in PDB entry 8fky, assembly 1, side view.
Probable rRNA-processing protein EBP2 in PDB entry 8fky, assembly 1, top view.
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Ribosome biogenesis protein BRX1 homolog
Chain: SO
Length: 353 amino acids
Theoretical weight: 41.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TDN6 (Residues: 1-353; Coverage: 100%)
Gene names: BRIX, BRIX1, BXDC2
Pfam: Brix domain
Ribosome biogenesis protein BRX1 homolog in PDB entry 8fky, assembly 1, front view.
Ribosome biogenesis protein BRX1 homolog in PDB entry 8fky, assembly 1, side view.
Ribosome biogenesis protein BRX1 homolog in PDB entry 8fky, assembly 1, top view.
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Ribosome biogenesis protein WDR12
Chain: SP
Length: 423 amino acids
Theoretical weight: 47.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9GZL7 (Residues: 1-423; Coverage: 100%)
Gene name: WDR12
Pfam:
Ribosome biogenesis protein WDR12 in PDB entry 8fky, assembly 1, front view.
Ribosome biogenesis protein WDR12 in PDB entry 8fky, assembly 1, side view.
Ribosome biogenesis protein WDR12 in PDB entry 8fky, assembly 1, top view.
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mRNA turnover protein 4 homolog
Chain: SQ
Length: 239 amino acids
Theoretical weight: 27.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UKD2 (Residues: 1-239; Coverage: 100%)
Gene names: C1orf33, MRT4, MRTO4
Pfam:
mRNA turnover protein 4 homolog in PDB entry 8fky, assembly 1, front view.
mRNA turnover protein 4 homolog in PDB entry 8fky, assembly 1, side view.
mRNA turnover protein 4 homolog in PDB entry 8fky, assembly 1, top view.
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GTP-binding protein 4
Chain: SR
Length: 634 amino acids
Theoretical weight: 74.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BZE4 (Residues: 1-634; Coverage: 100%)
Gene names: CRFG, GTPBP4, NOG1
Pfam:
GTP-binding protein 4 in PDB entry 8fky, assembly 1, front view.
GTP-binding protein 4 in PDB entry 8fky, assembly 1, side view.
GTP-binding protein 4 in PDB entry 8fky, assembly 1, top view.
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Ribosome biogenesis protein BOP1
Chain: SS
Length: 746 amino acids
Theoretical weight: 83.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q14137 (Residues: 1-746; Coverage: 100%)
Gene names: BOP1, KIAA0124
Pfam:
Ribosome biogenesis protein BOP1 in PDB entry 8fky, assembly 1, front view.
Ribosome biogenesis protein BOP1 in PDB entry 8fky, assembly 1, side view.
Ribosome biogenesis protein BOP1 in PDB entry 8fky, assembly 1, top view.
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Ribosome biogenesis regulatory protein homolog
Chain: ST
Length: 365 amino acids
Theoretical weight: 41.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15050 (Residues: 1-365; Coverage: 100%)
Gene names: KIAA0112, RRR, RRS1
Pfam: Ribosome biogenesis regulatory protein (RRS1)
Ribosome biogenesis regulatory protein homolog in PDB entry 8fky, assembly 1, front view.
Ribosome biogenesis regulatory protein homolog in PDB entry 8fky, assembly 1, side view.
Ribosome biogenesis regulatory protein homolog in PDB entry 8fky, assembly 1, top view.
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Nucleolar complex protein 3 homolog
Chain: SU
Length: 800 amino acids
Theoretical weight: 92.71 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8WTT2 (Residues: 1-800; Coverage: 100%)
Gene names: AD24, C10orf117, FAD24, NOC3L
Pfam:
Nucleolar complex protein 3 homolog in PDB entry 8fky, assembly 1, front view.
Nucleolar complex protein 3 homolog in PDB entry 8fky, assembly 1, side view.
Nucleolar complex protein 3 homolog in PDB entry 8fky, assembly 1, top view.
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Probable ribosome biogenesis protein RLP24
Chain: SV
Length: 163 amino acids
Theoretical weight: 19.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UHA3 (Residues: 1-163; Coverage: 100%)
Gene names: C15orf15, My024, RPL24L, RSL24D1
Pfam: Ribosomal protein L24e
Probable ribosome biogenesis protein RLP24 in PDB entry 8fky, assembly 1, front view.
Probable ribosome biogenesis protein RLP24 in PDB entry 8fky, assembly 1, side view.
Probable ribosome biogenesis protein RLP24 in PDB entry 8fky, assembly 1, top view.
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ATP-dependent RNA helicase DDX18
Chain: SW
Length: 670 amino acids
Theoretical weight: 75.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NVP1 (Residues: 1-670; Coverage: 100%)
Gene names: DDX18, cPERP-D
Pfam:
ATP-dependent RNA helicase DDX18 in PDB entry 8fky, assembly 1, front view.
ATP-dependent RNA helicase DDX18 in PDB entry 8fky, assembly 1, side view.
ATP-dependent RNA helicase DDX18 in PDB entry 8fky, assembly 1, top view.
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28S rRNA (cytosine(4447)-C(5))-methyltransferase
Chain: SY
Length: 812 amino acids
Theoretical weight: 89.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P46087 (Residues: 1-812; Coverage: 100%)
Gene names: NOL1, NOP2, NSUN1
Pfam:
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase in PDB entry 8fky, assembly 1, front view.
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase in PDB entry 8fky, assembly 1, side view.
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase in PDB entry 8fky, assembly 1, top view.
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Nucleolar protein 16
Chain: SZ
Length: 178 amino acids
Theoretical weight: 21.23 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y3C1 (Residues: 1-178; Coverage: 100%)
Gene names: CGI-117, HSPC111, NOP16
Pfam: Ribosome biogenesis protein Nop16
Nucleolar protein 16 in PDB entry 8fky, assembly 1, front view.
Nucleolar protein 16 in PDB entry 8fky, assembly 1, side view.
Nucleolar protein 16 in PDB entry 8fky, assembly 1, top view.
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RNA chain L1
Name: 5.8S ribosomal RNA
Representative chains: L1
Length: 157 nucleotides
Theoretical weight: 50.45 KDa
Rfam: 5.8S ribosomal RNA
5.8S ribosomal RNA in PDB entry 8fky, assembly 1, front view.
5.8S ribosomal RNA in PDB entry 8fky, assembly 1, side view.
5.8S ribosomal RNA in PDB entry 8fky, assembly 1, top view.
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RNA chain L2
Name: ITS2 rRNA
Representative chains: L2
Length: 1167 nucleotides
Theoretical weight: 376.43 KDa
ITS2 rRNA in PDB entry 8fky, assembly 1, front view.
ITS2 rRNA in PDB entry 8fky, assembly 1, side view.
ITS2 rRNA in PDB entry 8fky, assembly 1, top view.
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RNA chain L3
Name: 28S ribosomal RNA
Representative chains: L3
Length: 5070 nucleotides
Theoretical weight: 1640.22 KDa
Rfam: Eukaryotic large subunit ribosomal RNA
28S ribosomal RNA in PDB entry 8fky, assembly 1, front view.
28S ribosomal RNA in PDB entry 8fky, assembly 1, side view.
28S ribosomal RNA in PDB entry 8fky, assembly 1, top view.
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