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Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state

Source organism: Saccharomyces cerevisiae
Biochemical function: metal ion binding
Biological process: DNA replication initiation
Cellular component: alpha DNA polymerase:primase complex

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EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF04042
Domain description: DNA polymerase alpha/epsilon subunit B
Occurring in:
  1. DNA polymerase alpha subunit B
The deposited structure of PDB entry 8foh contains 1 copy of Pfam domain PF04042 (DNA polymerase alpha/epsilon subunit B) in DNA polymerase alpha subunit B. Showing 1 copy in chain D [auth C].

PF22062
Domain description: DNA polymerase alpha subunit B, OB domain
Occurring in:
  1. DNA polymerase alpha subunit B

PF04104
Domain description: Eukaryotic and archaeal DNA primase, large subunit
Occurring in:
  1. DNA primase large subunit
The deposited structure of PDB entry 8foh contains 1 copy of Pfam domain PF04104 (Eukaryotic and archaeal DNA primase, large subunit) in DNA primase large subunit. Showing 1 copy in chain C [auth B].

PF01896
Domain description: DNA primase small subunit
Occurring in:
  1. DNA primase small subunit
The deposited structure of PDB entry 8foh contains 1 copy of Pfam domain PF01896 (DNA primase small subunit) in DNA primase small subunit. Showing 1 copy in chain B [auth A].

PF08996
Domain description: DNA Polymerase alpha zinc finger
Occurring in:
  1. DNA polymerase alpha catalytic subunit A
The deposited structure of PDB entry 8foh contains 1 copy of Pfam domain PF08996 (DNA Polymerase alpha zinc finger) in DNA polymerase alpha catalytic subunit A. Showing 1 copy in chain A [auth 1].

PF00136
Domain description: DNA polymerase family B
Occurring in:
  1. DNA polymerase alpha catalytic subunit A
The deposited structure of PDB entry 8foh contains 1 copy of Pfam domain PF00136 (DNA polymerase family B) in DNA polymerase alpha catalytic subunit A. Showing 1 copy in chain A [auth 1].

PF03104
Domain description: DNA polymerase family B, exonuclease domain
Occurring in:
  1. DNA polymerase alpha catalytic subunit A
The deposited structure of PDB entry 8foh contains 1 copy of Pfam domain PF03104 (DNA polymerase family B, exonuclease domain) in DNA polymerase alpha catalytic subunit A. Showing 1 copy in chain A [auth 1].

PF12254
Domain description: DNA polymerase alpha subunit p180 N terminal
Occurring in:
  1. DNA polymerase alpha catalytic subunit A
The deposited structure of PDB entry 8foh contains 1 copy of Pfam domain PF12254 (DNA polymerase alpha subunit p180 N terminal) in DNA polymerase alpha catalytic subunit A. Showing 1 copy in chain A [auth 1] (this domain is out of the observed residue ranges!).

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