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GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610)

Electron Microscopy
2.4Å resolution
PDB entry 8fp4 coloured by chain, front view.
PDB entry 8fp4 coloured by chain, side view.
PDB entry 8fp4 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glutamate receptor 2 and Voltage-dependent calcium channel gamma-2 subunit
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Multimeric state: hetero octamer
Accessible surface area: 63114.3 Å2
Buried surface area: 28065.13 Å2
Dissociation area: 6,059.96 Å2
Dissociation energy (ΔGdiss): 100.78 kcal/mol
Dissociation entropy (TΔSdiss): 54.54 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-240471

Macromolecules

Glutamate receptor 2
Chains: A, B, C, D
Length: 889 amino acids
Theoretical weight: 99.56 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 1-868, 869-883; Coverage: 100%)
  • Best match: P19491-2 (Residues: 1-868, 869-883)
Gene names: GluA2, Glur2, Gria2
Pfam:
Glutamate receptor 2 in PDB entry 8fp4, assembly 1, front view.
Glutamate receptor 2 in PDB entry 8fp4, assembly 1, side view.
Glutamate receptor 2 in PDB entry 8fp4, assembly 1, top view.
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Voltage-dependent calcium channel gamma-2 subunit
Chains: E, F, G, H
Length: 336 amino acids
Theoretical weight: 37.11 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: O88602 (Residues: 1-323; Coverage: 100%)
Gene names: Cacng2, Stg
Pfam: PMP-22/EMP/MP20/Claudin family
Voltage-dependent calcium channel gamma-2 subunit in PDB entry 8fp4, assembly 1, front view.
Voltage-dependent calcium channel gamma-2 subunit in PDB entry 8fp4, assembly 1, side view.
Voltage-dependent calcium channel gamma-2 subunit in PDB entry 8fp4, assembly 1, top view.
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