8fx7 › Citations

Not always an innocent bystander: the impact of stabilised phosphopantetheine moieties when studying nonribosomal peptide biosynthesis.

Ho YTC, Kaczmarski JA, Tailhades J, Izoré T, Steer DL, Schittenhelm RB, Tosin M, Jackson CJ, Cryle MJ
Chem Commun (Camb) (2023)
Cited: 1 times
EuropePMC logo PMID: 37310188

Abstract

Nonribosomal peptide synthetases produce many important peptide natural products and are centred around carrier proteins (CPs) that deliver intermediates to various catalytic domains. We show that the replacement of CP substrate thioesters by stabilised ester analogues leads to active condensation domain complexes, whereas amide stabilisation generates non-functional complexes.

Articles - 8fx7 mentioned but not cited (1)

  1. Palliative radiotherapy indications during the COVID-19 pandemic and in future complex logistic settings: the NORMALITY model. Cellini F, Di Franco R, Manfrida S, Borzillo V, Maranzano E, Pergolizzi S, Morganti AG, Fusco V, Deodato F, Santarelli M, Arcidiacono F, Rossi R, Reina S, Merlotti A, Jereczek-Fossa BA, Tozzi A, Siepe G, Cacciola A, Russi E, Gambacorta MA, Scorsetti M, Ricardi U, Corvò R, Donato V, Muto P, Valentini V. Radiol Med 126 1619-1656 (2021)




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