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Crystal structure of human pro-TGF-beta2 in complex with Nb9

X-ray diffraction
3.15Å resolution
PDB entry 8fxs coloured by chain, front view.
PDB entry 8fxs coloured by chain, side view.
PDB entry 8fxs coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TGF-beta-2 complex and antibody
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Multimeric state: hetero tetramer
Accessible surface area: 42732.9 Å2
Buried surface area: 12155.3 Å2
Dissociation area: 1,732.02 Å2
Dissociation energy (ΔGdiss): 0.12 kcal/mol
Dissociation entropy (TΔSdiss): 24.42 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-225765

Macromolecules

Transforming growth factor beta-2 proprotein
Chains: A, B
Length: 393 amino acids
Theoretical weight: 45.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61812 (Residues: 21-414; Coverage: 99%)
Gene name: TGFB2
Pfam:
Transforming growth factor beta-2 proprotein in PDB entry 8fxs, assembly 1, front view.
Transforming growth factor beta-2 proprotein in PDB entry 8fxs, assembly 1, side view.
Transforming growth factor beta-2 proprotein in PDB entry 8fxs, assembly 1, top view.
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Nanobody clone 9
Chains: D, E
Length: 124 amino acids
Theoretical weight: 13.8 KDa
Source organism: synthetic construct
Expression system: Escherichia coli BL21(DE3)
Nanobody clone 9 in PDB entry 8fxs, assembly 1, front view.
Nanobody clone 9 in PDB entry 8fxs, assembly 1, side view.
Nanobody clone 9 in PDB entry 8fxs, assembly 1, top view.
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