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Crystal structure of human proTGF-beta2 in complex with Nb18

X-ray diffraction
2.2Å resolution
PDB entry 8fxv coloured by chain, front view.
PDB entry 8fxv coloured by chain, side view.
PDB entry 8fxv coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TGF-beta-2 complex and antibody
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Multimeric state: hetero tetramer
Accessible surface area: 40658.95 Å2
Buried surface area: 12178.93 Å2
Dissociation area: 1,776.22 Å2
Dissociation energy (ΔGdiss): 6.34 kcal/mol
Dissociation entropy (TΔSdiss): 24.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-276232

Macromolecules

Transforming growth factor beta-2 proprotein
Chain: A
Length: 393 amino acids
Theoretical weight: 45.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61812 (Residues: 21-414; Coverage: 99%)
Gene name: TGFB2
Pfam:
Transforming growth factor beta-2 proprotein in PDB entry 8fxv, assembly 1, front view.
Transforming growth factor beta-2 proprotein in PDB entry 8fxv, assembly 1, side view.
Transforming growth factor beta-2 proprotein in PDB entry 8fxv, assembly 1, top view.
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Nanobody clone 18
Chain: B
Length: 124 amino acids
Theoretical weight: 13.52 KDa
Source organism: synthetic construct
Expression system: Escherichia coli BL21(DE3)
Nanobody clone 18 in PDB entry 8fxv, assembly 1, front view.
Nanobody clone 18 in PDB entry 8fxv, assembly 1, side view.
Nanobody clone 18 in PDB entry 8fxv, assembly 1, top view.
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