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5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex

Electron Microscopy
2.79Å resolution
PDB entry 8fy8 coloured by chain, front view.
PDB entry 8fy8 coloured by chain, side view.
PDB entry 8fy8 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 40786.59 Å2
Buried surface area: 9417.68 Å2
Dissociation area: 1,226.68 Å2
Dissociation energy (ΔGdiss): 1.39 kcal/mol
Dissociation entropy (TΔSdiss): 13.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140422

Macromolecules

Guanine nucleotide-binding protein G(i) subunit alpha-1
Chain: A
Length: 354 amino acids
Theoretical weight: 40.41 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Pfam: G-protein alpha subunit
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8fy8, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8fy8, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8fy8, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 358 amino acids
Theoretical weight: 39.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8fy8, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8fy8, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8fy8, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 80 amino acids
Theoretical weight: 8.51 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8fy8, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8fy8, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8fy8, assembly 1, top view.
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5-hydroxytryptamine receptor 1A; Soluble cytochrome b562
Chain: R
Length: 552 amino acids
Theoretical weight: 61.38 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 13-127; Coverage: 98%)
  • Canonical: P08908 (Residues: 26-422; Coverage: 94%)
    • nullnull
Gene names: ADRB2RL1, ADRBRL1, HTR1A, cybC
Pfam:
5-hydroxytryptamine receptor 1A in PDB entry 8fy8, assembly 1, front view.
5-hydroxytryptamine receptor 1A in PDB entry 8fy8, assembly 1, side view.
5-hydroxytryptamine receptor 1A in PDB entry 8fy8, assembly 1, top view.
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