8fyh

Electron Microscopy
3.4Å resolution

G4 RNA-mediated PRC2 dimer

Released:
Source organism: Homo sapiens
Related structures: EMD-29578

Function and Biology Details

Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(27) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(27)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tridecamer (preferred)
PDBe Complex ID:
PDB-CPX-230600 (preferred)
Entry contents:
6 distinct polypeptide molecules
1 distinct RNA molecule
Macromolecules (7 distinct):
Polycomb protein SUZ12 Chains: B, H
Molecule details ›
Chains: B, H
Length: 739 amino acids
Theoretical weight: 83.18 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q15022 (Residues: 1-739; Coverage: 100%)
Gene names: CHET9, JJAZ1, KIAA0160, SUZ12
Sequence domains: VEFS-Box of polycomb protein
Polycomb protein EED Chains: C, I
Molecule details ›
Chains: C, I
Length: 441 amino acids
Theoretical weight: 50.27 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75530 (Residues: 1-441; Coverage: 100%)
Gene name: EED
Sequence domains: WD domain, G-beta repeat
Histone-binding protein RBBP4 Chains: D, J
Molecule details ›
Chains: D, J
Length: 425 amino acids
Theoretical weight: 47.71 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q09028 (Residues: 1-425; Coverage: 100%)
Gene names: RBAP48, RBBP4
Sequence domains:
Histone-lysine N-methyltransferase EZH2 Chains: A, G
Molecule details ›
Chains: A, G
Length: 751 amino acids
Theoretical weight: 86.15 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q15910 (Residues: 1-297, 298-746; Coverage: 100%)
  • Best match: Q15910-2 (Residues: 1-751)
Gene names: EZH2, KMT6
Sequence domains:
Protein Jumonji isoform X3 Chains: E, K
Molecule details ›
Chains: E, K
Length: 1238 amino acids
Theoretical weight: 138.41 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A6I9KXB3 (Residues: 1-1238; Coverage: 100%)
Gene name: Jarid2
Sequence domains:
Zinc finger protein AEBP2 Chains: F, L
Molecule details ›
Chains: F, L
Length: 517 amino acids
Theoretical weight: 54.54 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6ZN18 (Residues: 1-517; Coverage: 100%)
Gene name: AEBP2
G4 RNA Chain: M
Molecule details ›
Chain: M
Length: 24 nucleotides
Theoretical weight: 7.96 KDa

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-29578
Expression system: Trichoplusia ni