› › Structure analysis

G4 RNA-mediated PRC2 dimer

Electron Microscopy
3.4Å resolution
PDB entry 8fyh coloured by chain, front view.
PDB entry 8fyh coloured by chain, side view.
PDB entry 8fyh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tridecamer (preferred)
Entry contents: 6 distinct polypeptide molecules
1 distinct RNA molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero tridecamer
Accessible surface area: 159683.64 Å2
Buried surface area: 54871.64 Å2
Dissociation area: 664.98 Å2
Dissociation energy (ΔGdiss): -25.78 kcal/mol
Dissociation entropy (TΔSdiss): 33.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-230600

Macromolecules

Polycomb protein SUZ12
Chains: B, H
Length: 739 amino acids
Theoretical weight: 83.18 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q15022 (Residues: 1-739; Coverage: 100%)
Gene names: CHET9, JJAZ1, KIAA0160, SUZ12
Pfam: VEFS-Box of polycomb protein
Polycomb protein SUZ12 in PDB entry 8fyh, assembly 1, front view.
Polycomb protein SUZ12 in PDB entry 8fyh, assembly 1, side view.
Polycomb protein SUZ12 in PDB entry 8fyh, assembly 1, top view.
Molecule details ›

Search similar proteins

Polycomb protein EED
Chains: C, I
Length: 441 amino acids
Theoretical weight: 50.27 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75530 (Residues: 1-441; Coverage: 100%)
Gene name: EED
Pfam: WD domain, G-beta repeat
Polycomb protein EED in PDB entry 8fyh, assembly 1, front view.
Polycomb protein EED in PDB entry 8fyh, assembly 1, side view.
Polycomb protein EED in PDB entry 8fyh, assembly 1, top view.
Molecule details ›

Search similar proteins

Histone-binding protein RBBP4
Chains: D, J
Length: 425 amino acids
Theoretical weight: 47.71 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q09028 (Residues: 1-425; Coverage: 100%)
Gene names: RBAP48, RBBP4
Pfam:
Histone-binding protein RBBP4 in PDB entry 8fyh, assembly 1, front view.
Histone-binding protein RBBP4 in PDB entry 8fyh, assembly 1, side view.
Histone-binding protein RBBP4 in PDB entry 8fyh, assembly 1, top view.
Molecule details ›

Search similar proteins

Histone-lysine N-methyltransferase EZH2
Chains: A, G
Length: 751 amino acids
Theoretical weight: 86.15 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q15910 (Residues: 1-297, 298-746; Coverage: 100%)
  • Best match: Q15910-2 (Residues: 1-751)
Gene names: EZH2, KMT6
Pfam:
Histone-lysine N-methyltransferase EZH2 in PDB entry 8fyh, assembly 1, front view.
Histone-lysine N-methyltransferase EZH2 in PDB entry 8fyh, assembly 1, side view.
Histone-lysine N-methyltransferase EZH2 in PDB entry 8fyh, assembly 1, top view.
Molecule details ›

Search similar proteins

Protein Jumonji isoform X3
Chains: E, K
Length: 1238 amino acids
Theoretical weight: 138.41 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A6I9KXB3 (Residues: 1-1238; Coverage: 100%)
Gene name: Jarid2
Pfam:
Protein Jumonji isoform X3 in PDB entry 8fyh, assembly 1, front view.
Protein Jumonji isoform X3 in PDB entry 8fyh, assembly 1, side view.
Protein Jumonji isoform X3 in PDB entry 8fyh, assembly 1, top view.
Molecule details ›

Search similar proteins

Zinc finger protein AEBP2
Chains: F, L
Length: 517 amino acids
Theoretical weight: 54.54 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6ZN18 (Residues: 1-517; Coverage: 100%)
Gene name: AEBP2
Zinc finger protein AEBP2 in PDB entry 8fyh, assembly 1, front view.
Zinc finger protein AEBP2 in PDB entry 8fyh, assembly 1, side view.
Zinc finger protein AEBP2 in PDB entry 8fyh, assembly 1, top view.
Molecule details ›

Search similar proteins

RNA chain M
Name: G4 RNA
Representative chains: M
Length: 24 nucleotides
Theoretical weight: 7.96 KDa
G4 RNA in PDB entry 8fyh, assembly 1, front view.
G4 RNA in PDB entry 8fyh, assembly 1, side view.
G4 RNA in PDB entry 8fyh, assembly 1, top view.
Molecule details ›

Search similar RNA

Quick links