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Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v), based on consensus cryo-EM map with only Fab 1G01 resolved

Electron Microscopy
3Å resolution
PDB entry 8gat coloured by chain, front view.
PDB entry 8gat coloured by chain, side view.
PDB entry 8gat coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neuraminidase, Vasodilator-stimulated phosphoprotein and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dodecamer
Accessible surface area: 91511.11 Å2
Buried surface area: 33867.98 Å2
Dissociation area: 8,404.88 Å2
Dissociation energy (ΔGdiss): 6.24 kcal/mol
Dissociation entropy (TΔSdiss): 100.49 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-240455

Macromolecules

Neuraminidase; Vasodilator-stimulated phosphoprotein
Chain: A
Length: 466 amino acids
Theoretical weight: 51.8 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P50552 (Residues: 337-375; Coverage: 10%)
  • Canonical: G9LQ08 (Residues: 83-469; Coverage: 83%)
    • nullnull
Gene names: L998_47825gpNA, NA, VASP
Pfam:
Neuraminidase in PDB entry 8gat, assembly 1, front view.
Neuraminidase in PDB entry 8gat, assembly 1, side view.
Neuraminidase in PDB entry 8gat, assembly 1, top view.
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Fab 1G01, heavy chain
Chain: M
Length: 240 amino acids
Theoretical weight: 25.98 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab 1G01, heavy chain in PDB entry 8gat, assembly 1, front view.
Fab 1G01, heavy chain in PDB entry 8gat, assembly 1, side view.
Fab 1G01, heavy chain in PDB entry 8gat, assembly 1, top view.
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Fab 1G01, light chain
Chain: N
Length: 216 amino acids
Theoretical weight: 23.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab 1G01, light chain in PDB entry 8gat, assembly 1, front view.
Fab 1G01, light chain in PDB entry 8gat, assembly 1, side view.
Fab 1G01, light chain in PDB entry 8gat, assembly 1, top view.
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