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Cryo-EM structure of HU-CB2-G protein complex

Electron Microscopy
2.97Å resolution
PDB entry 8gus coloured by chain, front view.
PDB entry 8gus coloured by chain, side view.
PDB entry 8gus coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 46495.16 Å2
Buried surface area: 11224.04 Å2
Dissociation area: 1,007.83 Å2
Dissociation energy (ΔGdiss): -2.38 kcal/mol
Dissociation entropy (TΔSdiss): 13.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225605

Macromolecules

Guanine nucleotide-binding protein G(i) subunit alpha-1
Chain: A
Length: 354 amino acids
Theoretical weight: 40.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Pfam: G-protein alpha subunit
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8gus, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8gus, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8gus, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 1-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8gus, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8gus, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8gus, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: C
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8gus, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8gus, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8gus, assembly 1, top view.
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Cannabinoid receptor 2
Chain: R
Length: 360 amino acids
Theoretical weight: 39.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P34972 (Residues: 1-360; Coverage: 100%)
Gene names: CB2A, CB2B, CNR2
Pfam: 7 transmembrane receptor (rhodopsin family)
Cannabinoid receptor 2 in PDB entry 8gus, assembly 1, front view.
Cannabinoid receptor 2 in PDB entry 8gus, assembly 1, side view.
Cannabinoid receptor 2 in PDB entry 8gus, assembly 1, top view.
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scFv16
Chain: S
Length: 259 amino acids
Theoretical weight: 27.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
scFv16 in PDB entry 8gus, assembly 1, front view.
scFv16 in PDB entry 8gus, assembly 1, side view.
scFv16 in PDB entry 8gus, assembly 1, top view.
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