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The intermediate structure of hAE2 in basic pH

Electron Microscopy
3.25Å resolution
PDB entry 8gva coloured by chain, front view.
PDB entry 8gva coloured by chain, side view.
PDB entry 8gva coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Anion exchange protein 2
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Multimeric state: homo dimer
Accessible surface area: 49029.11 Å2
Buried surface area: 2317.29 Å2
Dissociation area: 1,158.64 Å2
Dissociation energy (ΔGdiss): 9.13 kcal/mol
Dissociation entropy (TΔSdiss): 14.71 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-199839

Macromolecules

Anion exchange protein 2
Chains: A, B
Length: 1241 amino acids
Theoretical weight: 137.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04920 (Residues: 1-1241; Coverage: 100%)
Gene names: AE2, EPB3L1, HKB3, MPB3L, SLC4A2
Pfam:
InterPro:
Anion exchange protein 2 in PDB entry 8gva, assembly 1, front view.
Anion exchange protein 2 in PDB entry 8gva, assembly 1, side view.
Anion exchange protein 2 in PDB entry 8gva, assembly 1, top view.
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