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Crystal structure of BCOR/PCGF1/KDM2B complex

X-ray diffraction
2.2Å resolution
PDB entry 8hcu coloured by chain, front view.
PDB entry 8hcu coloured by chain, side view.
PDB entry 8hcu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 22057.19 Å2
Buried surface area: 3681.4 Å2
Dissociation area: 338.96 Å2
Dissociation energy (ΔGdiss): -6.42 kcal/mol
Dissociation entropy (TΔSdiss): 12.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-274926

Macromolecules

Lysine-specific demethylase 2B
Chain: A
Length: 235 amino acids
Theoretical weight: 26.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NHM5 (Residues: 1103-1336; Coverage: 18%)
Gene names: CXXC2, FBL10, FBXL10, JHDM1B, KDM2B, NDY1, PCCX2
Lysine-specific demethylase 2B in PDB entry 8hcu, assembly 1, front view.
Lysine-specific demethylase 2B in PDB entry 8hcu, assembly 1, side view.
Lysine-specific demethylase 2B in PDB entry 8hcu, assembly 1, top view.
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Polycomb group RING finger protein 1
Chain: B
Length: 105 amino acids
Theoretical weight: 12.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BSM1 (Residues: 151-255; Coverage: 41%)
Gene names: NSPC1, PCGF1, RNF68
Pfam: RAWUL domain RING finger- and WD40-associated ubiquitin-like
Polycomb group RING finger protein 1 in PDB entry 8hcu, assembly 1, front view.
Polycomb group RING finger protein 1 in PDB entry 8hcu, assembly 1, side view.
Polycomb group RING finger protein 1 in PDB entry 8hcu, assembly 1, top view.
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BCL-6 corepressor
Chain: C
Length: 142 amino acids
Theoretical weight: 16.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6W2J9 (Residues: 1607-1748; Coverage: 8%)
Gene names: BCOR, KIAA1575
Pfam: BCORL-PCGF1-binding domain
BCL-6 corepressor in PDB entry 8hcu, assembly 1, front view.
BCL-6 corepressor in PDB entry 8hcu, assembly 1, side view.
BCL-6 corepressor in PDB entry 8hcu, assembly 1, top view.
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