8hez

Electron Microscopy
2.8Å resolution

Structure of human SGLT2-MAP17 complex with Dapagliflozin

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-152041 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sodium/glucose cotransporter 2 Chain: A
Molecule details ›
Chain: A
Length: 676 amino acids
Theoretical weight: 73.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31639 (Residues: 1-672; Coverage: 100%)
Gene names: SGLT2, SLC5A2
Sequence domains: Sodium:solute symporter family
PDZK1-interacting protein 1 Chain: B
Molecule details ›
Chain: B
Length: 114 amino acids
Theoretical weight: 12.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13113 (Residues: 1-114; Coverage: 100%)
Gene names: MAP17, PDZK1IP1
Sequence domains: Membrane-associated protein 117 kDa, PDZK1-interacting protein 1

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.8Å
Relevant EMDB volumes: EMD-34705
Expression system: Homo sapiens