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Structure of human SGLT2-MAP17 complex with Dapagliflozin

Electron Microscopy
2.8Å resolution
PDB entry 8hez coloured by chain, front view.
PDB entry 8hez coloured by chain, side view.
PDB entry 8hez coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SGLT2-MAP17 glucose cotransporter complex
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Multimeric state: hetero dimer
Accessible surface area: 24395.89 Å2
Buried surface area: 1103.63 Å2
Dissociation area: 469.78 Å2
Dissociation energy (ΔGdiss): 1.56 kcal/mol
Dissociation entropy (TΔSdiss): 9.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152041

Macromolecules

Sodium/glucose cotransporter 2
Chain: A
Length: 676 amino acids
Theoretical weight: 73.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31639 (Residues: 1-672; Coverage: 100%)
Gene names: SGLT2, SLC5A2
Pfam: Sodium:solute symporter family
Sodium/glucose cotransporter 2 in PDB entry 8hez, assembly 1, front view.
Sodium/glucose cotransporter 2 in PDB entry 8hez, assembly 1, side view.
Sodium/glucose cotransporter 2 in PDB entry 8hez, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P31639  
167650100150200250300350400450500550600650
 
200400600
UniProt
P31639
Chains
Secondary structure
Ligand binding sites
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PDZK1-interacting protein 1
Chain: B
Length: 114 amino acids
Theoretical weight: 12.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13113 (Residues: 1-114; Coverage: 100%)
Gene names: MAP17, PDZK1IP1
Pfam: Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
PDZK1-interacting protein 1 in PDB entry 8hez, assembly 1, front view.
PDZK1-interacting protein 1 in PDB entry 8hez, assembly 1, side view.
PDZK1-interacting protein 1 in PDB entry 8hez, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q13113  
1114102030405060708090100110
 
50100
UniProt
Q13113
Chains
Secondary structure
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