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Gi bound orphan GPR20 in ligand-free state

Electron Microscopy
3.14Å resolution
PDB entry 8hs3 coloured by chain, front view.
PDB entry 8hs3 coloured by chain, side view.
PDB entry 8hs3 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 46535.53 Å2
Buried surface area: 10626.48 Å2
Dissociation area: 1,039.6 Å2
Dissociation energy (ΔGdiss): -0.44 kcal/mol
Dissociation entropy (TΔSdiss): 13.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-272613

Macromolecules

Guanine nucleotide-binding protein G(i) subunit alpha-1
Chain: A
Length: 354 amino acids
Theoretical weight: 40.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Pfam: G-protein alpha subunit
InterPro:
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8hs3, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8hs3, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8hs3, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 340 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 1-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8hs3, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8hs3, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8hs3, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: C
Length: 81 amino acids
Theoretical weight: 8.72 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
InterPro:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8hs3, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8hs3, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8hs3, assembly 1, top view.
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G-protein coupled receptor 20; Soluble cytochrome b562
Chain: R
Length: 511 amino acids
Theoretical weight: 56.04 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 22-127; Coverage: 99%)
  • Canonical: Q99678 (Residues: 1-358; Coverage: 100%)
    • nullnull
Gene names: GPR20, cybC
Pfam:
InterPro:
G-protein coupled receptor 20 in PDB entry 8hs3, assembly 1, front view.
G-protein coupled receptor 20 in PDB entry 8hs3, assembly 1, side view.
G-protein coupled receptor 20 in PDB entry 8hs3, assembly 1, top view.
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scFv16
Chain: S
Length: 297 amino acids
Theoretical weight: 31.87 KDa
Source organism: Homo sapiens
Expression system: Vicugna pacos
InterPro:
scFv16 in PDB entry 8hs3, assembly 1, front view.
scFv16 in PDB entry 8hs3, assembly 1, side view.
scFv16 in PDB entry 8hs3, assembly 1, top view.
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