› 8hxa

Electron Microscopy
3.04Å resolution

Cryo-EM structure of MPXV M2 in complex with human B7.1

Released:
DOI: 10.2210/pdb8hxa/pdb
PDB entry 8hxa coloured by chain, front view.
PDB entry 8hxa coloured by chain, side view.
PDB entry 8hxa coloured by chain, top view.
Source organisms:
Primary publication:
Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2.
Yang S, Wang Y, Yu F, Cheng R, Zhang Y, Zhou D, Ren X, Deng Z, Zhao H
OpenAccess logo Nat Commun 14 5186 (2023)
PMID: 37626059
Related structures: EMD-35074

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-239841 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Early protein OPG038 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 203 amino acids
Theoretical weight: 23.29 KDa
Source organism: Monkeypox virus
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A7H0DN11 (Residues: 18-220; Coverage: 100%)
Gene names: M2L, MPXVgp026, OPG038
Sequence domains: Poxvirus M2 protein
T-lymphocyte activation antigen CD80 Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 200 amino acids
Theoretical weight: 22.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P33681 (Residues: 35-234; Coverage: 79%)
Gene names: CD28LG, CD28LG1, CD80, LAB7
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.04Å
Relevant EMDB volumes: EMD-35074
Expression system: Homo sapiens

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