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Cryo-EM structure of MPXV M2 in complex with human B7.1

Electron Microscopy
3.04Å resolution
PDB entry 8hxa coloured by chain, front view.
PDB entry 8hxa coloured by chain, side view.
PDB entry 8hxa coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Early protein OPG038 and T-lymphocyte activation antigen CD80
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Multimeric state: hetero dodecamer
Accessible surface area: 77998.79 Å2
Buried surface area: 19300.98 Å2
Dissociation area: 5,310.97 Å2
Dissociation energy (ΔGdiss): -30.85 kcal/mol
Dissociation entropy (TΔSdiss): 73.99 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-239841

Macromolecules

Early protein OPG038
Chains: A, B, C, D, E, F
Length: 203 amino acids
Theoretical weight: 23.29 KDa
Source organism: Monkeypox virus
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A7H0DN11 (Residues: 18-220; Coverage: 100%)
Gene names: M2L, MPXVgp026, OPG038
Pfam: Poxvirus M2 protein
Early protein OPG038 in PDB entry 8hxa, assembly 1, front view.
Early protein OPG038 in PDB entry 8hxa, assembly 1, side view.
Early protein OPG038 in PDB entry 8hxa, assembly 1, top view.
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T-lymphocyte activation antigen CD80
Chains: G, H, I, J, K, L
Length: 200 amino acids
Theoretical weight: 22.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P33681 (Residues: 35-234; Coverage: 79%)
Gene names: CD28LG, CD28LG1, CD80, LAB7
Pfam:
T-lymphocyte activation antigen CD80 in PDB entry 8hxa, assembly 1, front view.
T-lymphocyte activation antigen CD80 in PDB entry 8hxa, assembly 1, side view.
T-lymphocyte activation antigen CD80 in PDB entry 8hxa, assembly 1, top view.
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