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Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-heptylthiazole-4-carboxylic acid

X-ray diffraction
2.39Å resolution
PDB entry 8hxw coloured by chain, front view.
PDB entry 8hxw coloured by chain, side view.
PDB entry 8hxw coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Metallo-beta-lactamase type 2
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Multimeric state: monomeric
Accessible surface area: 9483.09 Å2
Buried surface area: 407.84 Å2
Dissociation area: 20.29 Å2
Dissociation energy (ΔGdiss): 1.34 kcal/mol
Dissociation entropy (TΔSdiss): -1.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-191748
Assembly 2
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Assembly Name: Metallo-beta-lactamase type 2
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Multimeric state: monomeric
Accessible surface area: 9331.44 Å2
Buried surface area: 205.1 Å2
Dissociation area: 87.73 Å2
Dissociation energy (ΔGdiss): 66.46 kcal/mol
Dissociation entropy (TΔSdiss): 1.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-191748

Macromolecules

Metallo-beta-lactamase type 2
Chains: A, B
Length: 231 amino acids
Theoretical weight: 24.68 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9K2N0 (Residues: 32-262; Coverage: 94%)
Gene names: PAERUG_P19_London_7_VIM_2_05_10_01672, bla vim-2, blaVIM-2, blm
Pfam: Metallo-beta-lactamase superfamily
Metallo-beta-lactamase domain-containing protein in PDB entry 8hxw, assembly 1, front view.
Metallo-beta-lactamase domain-containing protein in PDB entry 8hxw, assembly 1, side view.
Metallo-beta-lactamase domain-containing protein in PDB entry 8hxw, assembly 1, top view.
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