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Structural insights into human brain gut peptide cholecystokinin receptors

Electron Microscopy
3.1Å resolution
PDB entry 8ia7 coloured by chain, front view.
PDB entry 8ia7 coloured by chain, side view.
PDB entry 8ia7 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 47995.11 Å2
Buried surface area: 12307.08 Å2
Dissociation area: 957.58 Å2
Dissociation energy (ΔGdiss): -3.82 kcal/mol
Dissociation entropy (TΔSdiss): 13.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-272358

Macromolecules

Gastrin/cholecystokinin type B receptor
Chain: R
Length: 447 amino acids
Theoretical weight: 48.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P32239 (Residues: 1-447; Coverage: 100%)
Gene names: CCKBR, CCKRB
Pfam: 7 transmembrane receptor (rhodopsin family)
Gastrin/cholecystokinin type B receptor in PDB entry 8ia7, assembly 1, front view.
Gastrin/cholecystokinin type B receptor in PDB entry 8ia7, assembly 1, side view.
Gastrin/cholecystokinin type B receptor in PDB entry 8ia7, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 345 amino acids
Theoretical weight: 37.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8ia7, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8ia7, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8ia7, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: C
Length: 70 amino acids
Theoretical weight: 7.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 2-71; Coverage: 99%)
Gene name: GNG2
Pfam: GGL domain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8ia7, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8ia7, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8ia7, assembly 1, top view.
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scfv16
Chain: E
Length: 269 amino acids
Theoretical weight: 28.81 KDa
Source organism: Mus musculus
scfv16 in PDB entry 8ia7, assembly 1, front view.
scfv16 in PDB entry 8ia7, assembly 1, side view.
scfv16 in PDB entry 8ia7, assembly 1, top view.
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Guanine nucleotide-binding protein G(q) subunit alpha
Chain: A
Length: 353 amino acids
Theoretical weight: 41.24 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P50148 (Residues: 36-359; Coverage: 90%)
Gene names: GAQ, GNAQ
Pfam: G-protein alpha subunit
Guanine nucleotide-binding protein G(q) subunit alpha in PDB entry 8ia7, assembly 1, front view.
Guanine nucleotide-binding protein G(q) subunit alpha in PDB entry 8ia7, assembly 1, side view.
Guanine nucleotide-binding protein G(q) subunit alpha in PDB entry 8ia7, assembly 1, top view.
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Cholecystokinin-8
Chain: L
Length: 9 amino acids
Theoretical weight: 1.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P06307 (Residues: 96-103; Coverage: 8%)
Gene name: CCK
Cholecystokinin-8 in PDB entry 8ia7, assembly 1, front view.
Cholecystokinin-8 in PDB entry 8ia7, assembly 1, side view.
Cholecystokinin-8 in PDB entry 8ia7, assembly 1, top view.
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