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Cryo-EM structure of human HCAR2-Gi complex with acipimox

Electron Microscopy
3.23Å resolution
PDB entry 8ijb coloured by chain, front view.
PDB entry 8ijb coloured by chain, side view.
PDB entry 8ijb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 49533.55 Å2
Buried surface area: 10390.76 Å2
Dissociation area: 929.36 Å2
Dissociation energy (ΔGdiss): -3.34 kcal/mol
Dissociation entropy (TΔSdiss): 13.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-276226

Macromolecules

Hydroxycarboxylic acid receptor 2
Chain: A
Length: 294 amino acids
Theoretical weight: 34.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8TDS4 (Residues: 8-301; Coverage: 81%)
Gene names: GPR109A, HCA2, HCAR2, HM74A, NIACR1
Pfam: 7 transmembrane receptor (rhodopsin family)
Hydroxycarboxylic acid receptor 2 in PDB entry 8ijb, assembly 1, front view.
Hydroxycarboxylic acid receptor 2 in PDB entry 8ijb, assembly 1, side view.
Hydroxycarboxylic acid receptor 2 in PDB entry 8ijb, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: B
Length: 337 amino acids
Theoretical weight: 37.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 4-340; Coverage: 99%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8ijb, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8ijb, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8ijb, assembly 1, top view.
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Guanine nucleotide-binding protein G(i) subunit alpha-1
Chain: C
Length: 351 amino acids
Theoretical weight: 40.15 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 4-354; Coverage: 99%)
Gene name: GNAI1
Pfam: G-protein alpha subunit
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8ijb, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8ijb, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-1 in PDB entry 8ijb, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: G
Length: 56 amino acids
Theoretical weight: 6.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 8-63; Coverage: 79%)
Gene name: GNG2
Pfam: GGL domain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8ijb, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8ijb, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8ijb, assembly 1, top view.
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scFv16
Chain: S
Length: 248 amino acids
Theoretical weight: 26.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
scFv16 in PDB entry 8ijb, assembly 1, front view.
scFv16 in PDB entry 8ijb, assembly 1, side view.
scFv16 in PDB entry 8ijb, assembly 1, top view.
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