› 8j79

X-ray diffraction
1.99Å resolution

Bovine Xanthine Oxidoreductase Crystallized with oxypurinol

Released:
DOI: 10.2210/pdb8j79/pdb
PDB entry 8j79 coloured by chain, front view.
PDB entry 8j79 coloured by chain, side view.
PDB entry 8j79 coloured by chain, top view.
Source organism: Bos taurus
Entry authors: Okamoto K, Sekine M

Function and Biology Details

Reactions catalysed: 
Xanthine + NAD(+) + H(2)O = urate + NADH
Xanthine + H(2)O + O(2) = urate + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160413 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Xanthine dehydrogenase/oxidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 1332 amino acids
Theoretical weight: 146.97 KDa
Source organism: Bos taurus
Expression system: Bos taurus
UniProt:
  • Canonical: P80457 (Residues: 1-1332; Coverage: 100%)
Gene name: XDH
Sequence domains:

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD

Cofactor: Ligand MTE 2 x MTE
6 bound ligands:
Ligand FES 4 x FES
Ligand MOS 2 x MOS
Ligand CO3 2 x CO3
Ligand CA 4 x CA
Ligand 141 2 x 141
Ligand GOL 6 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C2
Unit cell:
a: 167.678Å b: 123.47Å c: 150.059Å
α: 90° β: 90.89° γ: 90°
R-values:
R R work R free
0.165 0.163 0.197
Expression system: Bos taurus

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