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Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state

Electron Microscopy
2.7Å resolution
PDB entry 8j7d coloured by chain, front view.
PDB entry 8j7d coloured by chain, side view.
PDB entry 8j7d coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Methylcrotonyl-CoA carboxylase complex
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Multimeric state: hetero dodecamer
Accessible surface area: 277472.44 Å2
Buried surface area: 72536.73 Å2
Dissociation area: 13,670.14 Å2
Dissociation energy (ΔGdiss): 157.87 kcal/mol
Dissociation entropy (TΔSdiss): 37.7 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-275276
Complex Portal ID: CPX-6236

Macromolecules

Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Chains: A, D, F, H, I, L
Length: 725 amino acids
Theoretical weight: 80.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96RQ3 (Residues: 1-725; Coverage: 100%)
Gene names: MCCA, MCCC1
Pfam:
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial in PDB entry 8j7d, assembly 1, front view.
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial in PDB entry 8j7d, assembly 1, side view.
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial in PDB entry 8j7d, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q96RQ3  
1725100200300400500600700
 
200400600
UniProt
Q96RQ3
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
Molecule details ›

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Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Chains: B, C, E, G, J, K
Length: 563 amino acids
Theoretical weight: 61.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HCC0 (Residues: 1-563; Coverage: 100%)
Gene names: MCCB, MCCC2
Pfam: Carboxyl transferase domain
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial in PDB entry 8j7d, assembly 1, front view.
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial in PDB entry 8j7d, assembly 1, side view.
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial in PDB entry 8j7d, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9HCC0  
156350100150200250300350400450500550
 
200400
UniProt
Q9HCC0
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
Molecule details ›

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