Structure analysis

Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state

Electron Microscopy
2.7Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero dodecamer
Accessible surface area: 277472.44 Å2
Buried surface area: 72536.73 Å2
Dissociation area: 13,670.14 Å2
Dissociation energy (ΔGdiss): 157.87 kcal/mol
Dissociation entropy (TΔSdiss): 37.7 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-275276
Complex Portal ID: CPX-6236

Macromolecules

Chains: A, D, F, H, I, L
Length: 725 amino acids
Theoretical weight: 80.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96RQ3 (Residues: 1-725; Coverage: 100%)
Gene names: MCCA, MCCC1
Pfam:
PDBe-KB: UniProt Coverage View: Q96RQ3  
1725100200300400500600700
 
200400600MAAASAVSVLLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNITKVLIANRGEIACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEESDKRESE
UniProt
Q96RQ3
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation

Search similar proteins

Chains: B, C, E, G, J, K
Length: 563 amino acids
Theoretical weight: 61.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HCC0 (Residues: 1-563; Coverage: 100%)
Gene names: MCCB, MCCC2
Pfam: Carboxyl transferase domain
PDBe-KB: UniProt Coverage View: Q9HCC0  
156350100150200250300350400450500550
 
200400MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERVEHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKLDVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFARIFGYPVGIVGNNGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAKDGAKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAANVLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGIIDPADTRLVLGLSFSAALNAPIEKTDFGIFRM
UniProt
Q9HCC0
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation

Search similar proteins